Synergistic effect of caffeic acid phenethyl ester with caspofungin against Candida albicans is mediated by disrupting iron homeostasis

- CAPE and CAS combination has a synergistic effect against C. albicans.
- CAPE treatment induces the perturbation of iron homeostasis in C. albicans.
- CAPE treatment decreases the mitochondrial respiration and increases ROS generation.
- CAPE potentiates the antifungal activities of CAS via mitochondrial dysfunction.