کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8548592 | 1561737 | 2017 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The aryloxyalkanoate dioxygenase-12 (AAD-12) protein is not acutely toxic in mice
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The aryloxyalkanoate dioxygenase-12 (AAD-12) protein is not acutely toxic in mice The aryloxyalkanoate dioxygenase-12 (AAD-12) protein is not acutely toxic in mice](/preview/png/8548592.png)
چکیده انگلیسی
Typically, when a protein is orally toxic, it acts via acute mechanisms, especially at high doses. Therefore, an acute oral toxicity study is considered appropriate for evaluating the safety of transgenic proteins. Soybean plants (events DAS-68416-4 and DAS-444Ã6-6) have been genetically modified to express the aryloxyalkanoate dioxygenase-12 (AAD-12) protein. The AAD-12 protein provides tolerance to the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D). This paper summarizes the study designs of two acute oral toxicity studies evaluating the AAD-12 protein and reports the results of these studies. No mortalities or adverse effects were observed in mice when AAD-12 was tested up to a limit dose of 5000Â mg/kg body weight. Based on the results of these studies, it can be concluded that AAD-12 protein, as expressed in genetically modified DAS-68416-4 and DAS-444Ã6-6 soybeans, lacks acute toxicity via the oral route.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 110, December 2017, Pages 200-203
Journal: Food and Chemical Toxicology - Volume 110, December 2017, Pages 200-203
نویسندگان
Sabitha Papineni, Rachel M. Golden, Johnson Thomas,