کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8548714 1561738 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
RIFM fragrance ingredient safety assessment, isobornyl isovalerate, CAS registry number 7779-73-9
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
RIFM fragrance ingredient safety assessment, isobornyl isovalerate, CAS registry number 7779-73-9
چکیده انگلیسی
This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization potential, as well as, environmental safety. Data from the suitable read across analog isobornyl acetate (CAS # 125-12-2) show that this material is not genotoxic, provided a MOE > 100 for the repeated dose, developmental and reproductive endpoints, and does not have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (threshold of Toxicological Concern) for a Cramer Class II material (0.47 mg/day). The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 110, Supplement 1, December 2017, Pages S1-S8
نویسندگان
, , , , , , , , , , , , , , , , , , ,