کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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856276 | 1470716 | 2015 | 8 صفحه PDF | دانلود رایگان |
Advanced additive manufacturing technologies, namely Biomanufacturing, are being used to fabricate scaffolds with controlled architecture for tissue engineering applications. These technologies combined with computer-aided design (CAD) enable to produce three-dimensional structures layer-by-layer in a multitude of biomaterials. Actual prediction of the effective mechanical properties of scaffolds produced by Biomanufacturing, is very important for tissue engineering applications. A novel computer based technique for scaffold design is topological optimisation. Topological optimisation is a form of “shape” optimisation, usually referred to as “layout” optimisation. The goal of topological optimisation is to find the best use of material for a body that is subjected to either a single load or a multiple load distribution. In this research work, a topological optimization strategy is presented to find out the best material use for a construct subject to either a single load or a multiple load distribution, maximising its mechanical behaviour under tensile and shear stress solicitations. The proposed topological optimization scheme enables the design of ideal topological architectures based on existing biologic Micro-CT data for the design of biomimetic scaffolds.
Journal: Procedia Engineering - Volume 110, 2015, Pages 159-166