کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8579978 | 1564443 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Marijuana derivatives in epilepsy treatment in childhood - Current knowledge
ترجمه فارسی عنوان
ماریجوانا مشتقات در درمان صرع در دوران کودکی - دانش فعلی
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
چکیده انگلیسی
Despite the availability of many antiepileptic medications and some alternative therapies, up to 30% of epilepsies are still treatment-resistant. In recent years the growing interest in the use of Cannabis extracts to treat drug-resistant epilepsy in humans appeared. The genus Cannabis contain more than 100 terpenoid compounds called 'cannabinoids' of which tetrahydrocannabinol (THC), cannabidiol (CBD), cannabinol, cannabidivarin (CBDV) and tetrahydrocannabidivarin showed anticonvulsant properties in variety of animal models. Furthermore, 3 of 4 randomized and blinded studies revealed antiepileptic efficacy of CBD also in humans, but the number of enrolled patients was very low. While the clinicians mostly understand need to conduct well-designed studies of CBD and THC, patients and their families tend to use cannabinoids without waiting for reliable scientific data. Although CBD appears to be a good candidate for a new antiepileptic drug, up to now there are not available clinical trials assessing its long-term effects. Keeping this in mind, in this paper we try to present current knowledge on 'medical' marijuana in epilepsy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pediatria Polska - Volume 91, Issue 6, NovemberâDecember 2016, Pages 574-580
Journal: Pediatria Polska - Volume 91, Issue 6, NovemberâDecember 2016, Pages 574-580
نویسندگان
Anna Makulec, WÅadysÅaw LasoÅ, Sergiusz Jóźwiak,