Płodowo-noworodkowa małopłytkowość alloimmunologiczna jako problem pediatryczno-położniczy - opisy przypadków

Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is the most common reason of isolated severe thrombocytopenias in neonates. It is caused by maternal alloantibodies against paternally inherited platelet antigens, resulting in platelet destruction. It might occur in the first pregnancy. Intracranial hemorrhage (ICH) is the most destructive consequence of FNAIT. It is noteworthy that FNAIT is one of the most common causes of ICH in an otherwise healthy full-term neonate. In the subsequent pregnancy, there is a higher risk of severe FNAIT-related complications, and so a maternal treatment in future pregnancies as prevention for FNAIT is very significant. We present three case reports of neonatal alloimmune thrombocytopenia and the current schemes of the prophylaxis against FNAIT and we also focus on the new prevention program in Poland.