3-Dimensional Laser Structured Scaffolds Improve Macrophage Adherence and Antigen-specific Response

Biomaterial surface properties are determined by the synergistic effect of the morphology and chemistry. Specific combinations of chemical and topographical cues, similar to those experienced by cells during in vivo development, have been shown to control cellular adhesion, migration and function. The aim of the study was to investigate whether 3D micro and submicron laser textured transplantable Si scaffolds with tunable morphology and chemistry could support macrophage adherence, antigen presentation and specific antibody production. The 3D scaffolds could provide useful materials for in vitro and in vivo applications.