Partitioning of Substrate within Aqueous Micelle Systems by Using Dead-End and Cross Flow Membrane Filtrations

The partition coefficients of different solutes as Itaconic acid (IA), dimethyl itaconate (DMI), diethyl itaconate (DEI) and dibuthyl itaconate (DBI) between water and micelles of Triton X-100 are determined by the two methods of separation namely Cross Flow Filtration and Dead-End Filtration by using a membrane that rejects the micelles and lets passing the molecules of solute. Partition coefficient of the solute between the aqueous phase and micelle aggregate was determined by titration and HPLC methods. The results obtained are discussed in our researcher's group and compared to others made with theoretical data reported from simulation. The effect of the different concentrations of solutes and transmembrane pressures have been investigated using a commercial membrane Nadir C005 (MWCO = 5 kDa).