کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8624376 | 1152630 | 2016 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Exosomes from oral squamous carcinoma cell lines, SQUU-A and SQUU-B, define the tropism of lymphatic dissemination
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوشیمی بالینی
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چکیده انگلیسی
Oral squamous cell carcinoma (OSCC) is often associated with lymphatic rather than hematogenous metastasis; however, a determinant factor for this process has not been elucidated. This study examined the effect of OSCC-derived exosomes on angiogenesis and lymphangiogenesis, closely related with hematogenous and lymphatic metastasis, respectively. Our data demonstrated that OSCC-derived exosomes stimulated the expression of VEGFs and their receptors, essential regulators of angiogenesis and lymphangiogenesis, in human lymphatic endothelial cells but not in human vein endothelial cells. These results suggest that specific exosomes have differential tropism toward a certain cell type, defining the modality of metastasis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Oral Biosciences - Volume 58, Issue 4, November 2016, Pages 180-184
Journal: Journal of Oral Biosciences - Volume 58, Issue 4, November 2016, Pages 180-184
نویسندگان
Masahiko Morioka, Tomoyo Kawakubo-Yasukochi, Yoshikazu Hayashi, Mai Hazekawa, Takuya Nishinakagawa, Kazuhiko Ono, Shintaro Kawano, Seiji Nakamura, Manabu Nakashima,