Abnormalities of tumor endothelial cells and cancer progression

However, tumor blood vessels have a distinctively abnormal phenotype, including morphological alterations. Recently, it has been revealed that TECs constitute a heterogeneous population, exhibiting characteristics that are largely induced by tumor microenvironmental factors. Furthermore, TECs induce cancer progression through metastasis. In this review, we describe recent studies on TEC abnormalities related to cancer progression and consider their therapeutic implications.