کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8626549 | 1568547 | 2017 | 35 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Immune-modulatory effects of syncytiotrophoblast extracellular vesicles in pregnancy and preeclampsia
ترجمه فارسی عنوان
اثرات ایمنی مولکولی حاملگی خارج سلولی سینسیتیروپروفوبلاست در حاملگی و پره اکلامپسی
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کلمات کلیدی
SyncytiotrophoblastNTANKTmicrovesiclesFlt-1TregInnate immunity - ایمنی ذاتیadaptive immunity - ایمنی سازگاریinterleukin - اینترلوکینPregnancy - بارداریNanoparticle tracking analysis - تجزیه و تحلیل ردیابی نانو ذراتsoluble fms-like tyrosine kinase 1 - تریستروژن کیناز 1 به صورت fms مانند محلول استtumor necrosis factor α - تومور نکروز عامل αExtracellular vesicles - حامل های خارج سلولیcluster of differentiation - خوشه تمایزRegulatory T cell - سلول T تنظیم کنندهNatural killer cell - سلول قاتل طبیعیnatural killer T cells - سلول های T قاتل طبیعیT helper cell - سلول کمکیTNF-α - فاکتور نکروز توموری آلفاSTB - و غیره.pre-eclampsia - پره اکلامپسیPreeclampsia - پری اکلامپسی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
چکیده انگلیسی
Unique immunologic adaptations exist to successfully establish and maintain pregnancy and to avoid an immune attack against the semi allogenic fetus. These adaptations occur both locally at the maternofetal interface and in the peripheral circulation and affect the innate as well as the adaptive immune system. Pregnancy is characterized by a general inflammatory state with activation of monocytes and granulocytes, but also with suppressive lymphocytes (regulatory T cells), and skewing towards T helper 2 immunity. The pregnancy complication preeclampsia is associated with an exaggerated inflammatory state and predominance of T helper 1 and 17 immunity. The syncytiotrophoblast has been found to secrete extracellular vesicles as communication factors into the maternal circulation. Syncytiotrophoblast extracellular vesicles from normal pregnancy have been shown to interact with monocytes, granulocytes, T cells and natural killer cells and influence the function of these cells. In doing so, they may support the inflammatory state of normal pregnancy as well as the suppressive lymphocyte phenotype. During preeclampsia, syncytiotrophoblast extracellular vesicles are not only increased in numbers but also showed an altered molecular load. Based on data from in vitro studies, it can be suggested that syncytiotrophoblast extracellular vesicles from preeclamptic pregnancies may support the exaggerated inflammatory state during preeclampsia. In this review, we discuss the immunological functions of syncytiotrophoblast extracellular vesicles and their involvement in adapting the maternal peripheral immunological adaptations to pregnancy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Placenta - Volume 60, Supplement 1, December 2017, Pages S41-S51
Journal: Placenta - Volume 60, Supplement 1, December 2017, Pages S41-S51
نویسندگان
Claudia Göhner, Torsten Plösch, Marijke M. Faas,