کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8628742 1568703 2018 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chemokines beyond chemo-attraction: CXCL10 and its significant role in cancer and autoimmunity
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Chemokines beyond chemo-attraction: CXCL10 and its significant role in cancer and autoimmunity
چکیده انگلیسی
CXCR3 is a chemokine receptor that is abundant on CD4+ T cells, CD8+ T cells and NK cells. It has three known ligands: CXCL9, CXCL10 and CXCL11. Different studies, including those coming form our laboratory, indicated that aside of attracting CD8+ and CD4+ effector T cells to tumor sites and sites of inflammation CXCL10 directs the polarization and potentiates the biological function of these cells. This makes CXCL10 a “key driver chemokine” and a valid target for therapy of autoimmune diseases such as Inflammatory Bowl's Disease, Multiple Sclerosis, Rheumatoid arthritis and others. As for cancer this motivated different groups, including our group to develop CXCL10 based therapies for cancer due to its ability to enhance T-dependent anti cancer immunity. The current review summarizes these findings and their potential translational implication.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 109, September 2018, Pages 24-28
نویسندگان
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