کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8629032 | 1568707 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Low level of serum HDL-cholesterol with increased sIL-2R predicts a poor clinical outcome for patients with malignant lymphoma and adult T-cell leukemia-lymphoma
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
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چکیده انگلیسی
Low concentrations of high-density lipoprotein cholesterol (HDL-C) have been reported in patients with hematological malignancies. However, the proof of decreased HDL-C in hematological malignancies and its association with clinical outcomes remain unclear. We analyzed 140 Japanese patients with malignant lymphoma (ML) and adult T-cell leukemia-lymphoma (ATLL). HDL-C, LDL-C and soluble interleukin-2 receptor (sIL-2R) were measured. Treatment decisions were determined with established protocols. HDL-C was 0.98â¯Â±â¯0.45â¯mmol/l in patients and 1.51â¯Â±â¯0.35â¯mmol/l in controls (Pâ¯<â¯0.001). LDL-C was lower in patients than in controls (2.76â¯Â±â¯0.96, 3.16â¯Â±â¯0.76â¯mmol/l, respectively, Pâ¯<â¯0.001). HDL-C was the lowest in ATLL (0.81â¯Â±â¯0.37â¯mmol/l), modest in non-Hodgkin lymphoma (1.09â¯Â±â¯0.42â¯mmol/l) and the highest in Hodgkin's disease (1.14â¯Â±â¯0.68â¯mmol/l), (Pâ¯=â¯0.0019). Inverse correlation was found between HDL-C and sIL-2R (râ¯=â¯â0.6584, Pâ¯<â¯0.001). Categorized patients into 3 subgroups according to HDL-C (<0.52, 0.52-1.02 and â¥1.03â¯mmol/l), sIL-2R were the highest (median, 36,675; IQR, 17,180-92,600 U/mL) in patients with HDL-Câ¯<â¯0.52â¯mmol/l, modest (2386, 1324-8340) in HDL-C 0.52-1.02â¯mmol/l and the lowest (761, 450-1596) in HDL-Câ¯â¥â¯1.03â¯mmol/l (Pâ¯<â¯0.001). In Cox regression model, the lowest HDL-C levels, <0.52â¯mmol/l, were associated with poorer clinical outcome and the hazard ratio was 5.73 (95%CI, 3.09-10.50; Pâ¯<â¯0.001). In Kaplan-Meier analysis according to HDL-C tertiles (<0.78, 0.78-1.10 and â¥1.11â¯mmol/l), patients with lowest HDL-C tertile showed inferior overall survival with a median follow-up of 23â¯months (Pâ¯<â¯0.001). We concluded that cytokine-induced low levels of HDL-C in patients with ML and ATLL has independent prognostic significance, and suggesting an early indicator of poorer outcome.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 105, May 2018, Pages 57-62
Journal: Cytokine - Volume 105, May 2018, Pages 57-62
نویسندگان
Ichiro Komiya, Takeaki Tomoyose, Gen Ouchi, Tomohiro Yara, Seishou Higa,