کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8629493 | 1568713 | 2017 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Production and regulation of interleukin-1 family cytokines at the materno-fetal interface
ترجمه فارسی عنوان
تولید و تنظیم سیتوکین های خانواده اینترلوکین-1 در رابط مادر و جنین
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کلمات کلیدی
IL-18IL-36Rainterleukin-1 receptor accessory proteinIL-18BPIL-38IL-36RIL-37IL-1 familyPPROMPROMIL-1RIL-1RAcPST2IL-33IL-1βIL-1αIL-1RAECs - EC هاReproductive immunology - ایمونولوژی تولید مثلInterleukin-37 - اینترلوکین -37Interleukin-33 - اینترلوکین 33Interleukin-18 - اینترلوکین ۱۸interleukin-1beta - اینترلوکین-1 بتاelective caesarean section - بخش سزارین انتخابیPlacenta - جفت Cytokines - سیتوکین هاPremature rupture of membranes - پارگی زودرس غشاءinterleukin-1 receptor - گیرنده اینترلوکین-1
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
چکیده انگلیسی
IL-1 family members regulate innate immune responses, are produced by gestation-associated tissues, and have a role in healthy and adverse pregnancy outcomes. To better understand their role at the materno-fetal interface we used a human tissue explant model to map lipopolysaccharide (LPS)-stimulated production of IL-1α, IL-1β, IL-18, IL-33, IL-1Ra, IL-18BPa, ST2 and IL-1RAcP by placenta, choriodecidua and amnion. Caspase-dependent processing of IL-1α, IL-1β, IL-18, and IL-33 and the ability of IL-1α, IL-1β, IL-18, and IL-33 to regulate the production of IL-1RA, IL-18BPa, ST2 and IL-1RAcP was also determined. LPS acted as a potent inducer of IL-1 family member expression especially in the placenta and choriodecidua with the response by the amnion restricted to IL-1β. Caspases-1, 4 and 8 contributed to LPS-stimulated production of IL-1β and IL-18, whereas calpain was required for IL-1α production. Exogenous administration of IL-1α, IL-1β, IL-18, and IL-33 lead to differential expression of IL-1Ra, IL-18BPa, ST2 and IL-1RAcP across all tissues examined. Most notable were the counter-regulatory effect of LPS on IL-1β and IL-1Ra in the amnion and the broad responsiveness of the amnion to IL-1 family cytokines for increased production of immunomodulatory peptides and soluble receptors. The placenta and membranes vary not only in their output of various IL-1 family members but also in their counter-regulatory mechanisms through endogenous inhibitory peptides, processing enzymes and soluble decoy receptors. This interactive network of inflammatory mediators likely contributes to innate defence mechanisms at the materno-fetal interface to limit, in particular, the detrimental effects of microbial invasion.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 99, November 2017, Pages 194-202
Journal: Cytokine - Volume 99, November 2017, Pages 194-202
نویسندگان
Louis M. Scott, Aled H. Bryant, April Rees, Billy Down, Ruth H. Jones, Catherine A. Thornton,