کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8631631 | 1568941 | 2018 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Biomarkers of GH action in children and adults
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Biomarkers of GH action in children and adults Biomarkers of GH action in children and adults](/preview/png/8631631.png)
چکیده انگلیسی
Growth hormone (GH) and IGF-I levels in serum are used as biomarkers in the diagnosis and management of GH-related disorders but have not been subject to structured validation. Auxological parameters in children and changes in body composition in adults, as well as metabolic parameters and patient related outcomes are used as clinical and surrogate endpoints. New treatment options, such as long acting GH and GH antagonists, require reevaluation of the currently used biochemical biomarkers. This article will review biomarkers, surrogate endpoints and clinical endpoints related to GH treatment in children and adults as well as in acromegaly.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Growth Hormone & IGF Research - Volume 40, June 2018, Pages 1-8
Journal: Growth Hormone & IGF Research - Volume 40, June 2018, Pages 1-8
نویسندگان
Katharina Schilbach, Daniel S. Olsson, Margaret C.S. Boguszewski, Martin Bidlingmaier, Gudmundur Johannsson, Jens-Otto Lunde Jørgensen,