کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8633256 1569053 2018 20 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Galanin decreases spontaneous resting contractions and potentiates acetyl choline-induced contractions of goldfish gut
ترجمه فارسی عنوان
گالانین کاهش انقباض استراحت خود به خودی و افزایش انقباضات ناشی از استیل کولین از روده طلایی ماهی
کلمات کلیدی
گالانیان، استیل کولین، حرکت روده، حمام ارگان ماهی،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی
Galanin (GAL) is a 29 amino acid peptide, first identified from the porcine intestine and widely distributed within the brain and peripheral tissues. Among GAL biological functions, its role as a potent appetite-stimulating peptide is probably the most studied. With galanin's established role in the modulation of food intake in fish, this study aims to evaluate the effects of GAL on the intestinal motility of the goldfish, Carassius auratus, using an organ bath system. Our results found that application of GAL to the organ bath causes a significant concentration-dependent decrease in the amplitude of spontaneous contractions of goldfish gut. Preincubations of intestinal strips with acetylcholine (ACh) and GAL showed that GAL increases the force of ACh-induced contractions of the goldfish gut. These results provide the first evidence for a role of GAL in gut motility in goldfish. This also suggests a crosstalk between the effects of GAL and ACh in such functions, thus pointing to a putative joint role between the two molecules. These findings offer novel information that strengthens the role of the galaninergic system in fish feeding.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropeptides - Volume 69, June 2018, Pages 92-97
نویسندگان
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