The Synthesis of Pentaerythrityl Tetraimdazole

A method for the preparation of pentaerythrityl tetraimidazole was reported with pentaerythritol and imidazole as raw material. Pentaerythrityl tetrabromide(PEBr4) was first prepared starting from pentaerythritol via two steps. Pentaerythrityl tetrabromide was then treated with imidazole, which was converted to pentaerythrityl tetraimidazole. The overall yield was 68.6%. The target product was analyzed and characterized by 1H-NMR and 13C-NMR methods, indicating that our route of synthesis is reasonable and feasible.