کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8644447 | 1569760 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Decreased circular RNA hsa_circ_0001649 predicts unfavorable prognosis in glioma and exerts oncogenic properties in vitro and in vivo
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کلمات کلیدی
FBSSHPRHhsa_circ_0001649nHA - NHACircular RNA - RNA دایره ایcircular RNAs - RNA های دایره ایImmunohistochemistry - ایمونوهیستوشیمیIHC - ایمونوهیستوشیمیfetal bovine serum - سرم جنین گاوcircRNAs - سیرک هاNormal Human astrocytes - عادی آستروسیت های انسانیconfidence interval - فاصله اطمینانhazard ratio - نسبت خطرPropidium iodide - پروتئین یدیدprognosis - پیش شناخت بیماریGlioma - گلیوما
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Glioma is a devastating disease with increasing incidence worldwide. Circular RNAs (circRNAs) was demonstrated to be involved in a wide range of pathophysiological processes, including tumorigenesis and development. Recently, the abnormally expressed hsa_circ_0001649 was found in several malignancies. In the current study, the expression levels of hsa_circ_0001649 in glioma and its clinical significance were explored. The biological functions including cell growth, colony-forming ability and apoptosis altered by hsa_circ_0001649 were further investigated in vitro. Tumor formation assay was also carried out to elucidate the oncogenic properties of hsa_circ_0001649. The data documented a decrease of hsa_circ_0001649 expression in glioma specimens and cell lines. In addition, down-regulated hsa_circ_0001649 is linked to larger tumor size (pâ¯=â¯0.002) and advanced WHO grade (pâ¯=â¯0.023). Additionally, hsa_circ_0001649 may be an independent prognostic marker for glioma patients after surgery (pâ¯=â¯0.046). Moreover, up-regulated hsa_circ_0001649 inhibits glioma cell growth in vitro and in vivo. Importantly, increased expression of hsa_circ_0001649 facilitates apoptosis by regulating Bcl-2/caspase-3 pathway. Ultimately, this study suggests that hsa_circ_0001649 may be a potential glioma-related prognostic/therapeutic target.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 676, 15 November 2018, Pages 117-122
Journal: Gene - Volume 676, 15 November 2018, Pages 117-122
نویسندگان
Yu Wang, Xin Sui, Hong Zhao, Ling Cong, Yu Li, Ting Xin, Mingxing Guo, Wenbo Hao,