کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8644931 | 1569771 | 2018 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of infusion speed of 7.5% hypertonic saline on brain edema in patients with craniocerebral injury: An experimental study
ترجمه فارسی عنوان
اثر سرعت انفوزیون 7/5٪ سالین هیپرتونیک بر ادم مغزی در بیماران مبتلا به آسیب مغزی: یک مطالعه تجربی
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کلمات کلیدی
IL-6ICPIL-1βAquaporin-4TNF-aNKCCAQP-4TBITraumatic brain injury - آسیب تروماتیک مغزbrain injury - آسیب مغزیBrain edema - ادم مغزیinterleukin-6 - اینترلوکین ۶Interleukin-1β - اینترلوکین-1βtumour necrosis factor-α - تومور نکروز عامل αintracranial pressure - فشار درون جمجمهایHypertonic saline - هیپرتونیک نمک
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
چکیده انگلیسی
This study firstly used a rat traumatic brain injury model to compare the therapeutic effects of different intravenous infusion speed of 7.5% hypertonic saline (HS). Then the authors applied different delivery rate of 7.5% HS to two groups of patients to figure out the optimal infusion rates. A total of 100 rats were randomly divided into control group, group A (7.5% HS 6â¯mL/h), group B (7.5% HS 3â¯mL/h), and group C (7.5% HS 2â¯mL/h). All rats were established for the brain injury model. A total of 30 patients were selected and randomly divided into group A (250â¯mL/h) and group B (125â¯mL/h), with 15 cases in each group. Urine amount was recorded per hour; furthermore, blood was extracted from the patients to measure the levels of AQP4, NKCC1, tumour necrosis factor-α (TNF-a), interleukin-1β (IL-1β), and interleukin-6 (IL-6). Compared with other groups, the expression levels of NKCC1 and AQP4 mRNA in group A was the lowest (Pâ¯<â¯0.05). NKCC1 and AQP4 protein expression levels were the lowest in all the groups (Pâ¯<â¯0.05). On the aspect of patients, group A displayed more significant difference compared with B group in terms of AQP4, NKCC1, TNF-a, IL-1β, and IL-6 (Pâ¯<â¯0.05). In the two groups, a significant difference was noted in the urine amount at 4â¯h after administration (Pâ¯<â¯0.05). In our study, infusion of hypertonic saline (250â¯mL/h) at the optimal rate of 7.5% HS decreased the intracranial pressure, brain tissue edema, and inflammatory cytokine expression; moreover, it can promote brain tissue protection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 665, 30 July 2018, Pages 201-207
Journal: Gene - Volume 665, 30 July 2018, Pages 201-207
نویسندگان
Zhenzhen Jiang, Hongmei Xu, Meilin Wang, Zefu Li, Xinyang Su, Xiaoli Li, Zhenzhu Li, Xuexin Han,