کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8645145 | 1569776 | 2018 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The acroframosome-acroplaxome-manchette axis may function in sperm head shaping and male fertility
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کلمات کلیدی
AFSLINCIFTUBPLCXG-actinMTOCAAMTGNPRMIMTF-actinfilamentous actin - actin filamentousubiquitin-proteasome pathway - ubiquitin-پروتئازوم مسیرSpermiogenesis - اسپرمیوژنزintraflagellar transport - حمل داخل قطارMicrotubule - ریزلوله یا میکروتوبولTrans-Golgi network - شبکه Trans-GoljiManchette - عنوانlinker of nucleoskeleton and cytoskeleton - لینک دهنده هسته سلول و سی تی اسکنmicrotubule organizing center - مرکز برگزاری میکروتوبول هاMaps - نقشه هاfollicle-stimulating hormone - هورمون تحریک کننده فولیکولFSH - هورمون محرکه فولیکولی microtubule-associated proteins - پروتئین های مرتبط با میکروتوبولTransition protein - پروتئین گذارProtamine - پروتامینCytoskeleton - چارچوب یاخته، سیتواسکلتون، اسکلت سلولی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Sperm malformation is one of the main reasons for male infertility, but the precise mechanisms of this process remain undiscovered. The major process of spermiogenesis is sperm head shaping. Cytoskeleton is a crucial unit in this process, as the acroplaxome and manchette are two kinds of momentous structures cooperated with various functional proteins to insure the formation of acrosome and nucleus. One is primarily formed by filamentous actin (F-actin) and responsible for transverse acrosome extension and concentration, another plays as the mainstay of nuclear deformation through circular arrangement of microtubules (MTs). We suspect that the acroplaxome alone cannot maintain such a spatial framework of the acrosome. Previous studies have also revealed that a nucleus without acrosome could not induce the formation of ectoplasmic specialization. In this review, we integrated most of the key proteins that have been proven to participate in the essential developmental steps of post-meiosis. We also propose that the ambient MTs of the acrosome might be emanated from the Golgi apparatus. They form a novel cytoskeleton termed acroframosome (AFS) to transport vesicles and proteins during acrosome biogenesis. The hypothesis of the acroframosome-acroplaxome-manchette (AAM) cytoskeletal system is likely to be the axis of head-to-tail spermiogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 660, 20 June 2018, Pages 28-40
Journal: Gene - Volume 660, 20 June 2018, Pages 28-40
نویسندگان
Ya-Lan Wei, Wan-Xi Yang,