کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8645301 | 1569780 | 2018 | 21 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
C-RAF function at the genome-wide transcriptome level: A systematic view
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کلمات کلیدی
EGFRAFHTLV-IASK-1human T cell leukemia virus type Ic-Raf - C-RafMAPK - MAPKTranscriptome - ترانسکریپتومepidermal growth factor - عامل رشد اپیدرمیrapidly accelerated fibrosarcoma - فیبروسارکوم سریعا شتاب می گیردMEK - مجاهدین خلقmitogen-activated protein kinase - پروتئین کیناز فعال با mitogenmitogen-activated protein kinase kinase - پروتئین کیناز کیناز فعال Mitogen فعالGene expression control - کنترل بیان ژنapoptosis signal-regulating kinase 1 - کیناز تنظیم کننده سیگنال آپوپتوز 1
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: C-RAF function at the genome-wide transcriptome level: A systematic view C-RAF function at the genome-wide transcriptome level: A systematic view](/preview/png/8645301.png)
چکیده انگلیسی
C-RAF was the first member of the RAF kinase family to be discovered. Since its discovery, C-RAF has been found to regulate many fundamental cell processes, such as cell proliferation, cell death, and metabolism. However, the majority of these functions are achieved through interactions with different proteins; the genes regulated by C-RAF in its active or inactive state remain unclear. In the work, we used RNA-seq analysis to study the global transcriptomes of C-RAF bearing or C-RAF knockout cells in quiescent or EGF activated states. We identified 3353 genes that are promoted or suppressed by C-RAF. Gene ontology and Kyoto Encyclopedia of Genes and Genomes analyses revealed that these genes are involved in drug addiction, cardiomyopathy, autoimmunity, and regulation of cell metabolism. Our results provide a panoramic view of C-RAF function, including known and novel functions, and have revealed potential targets for elucidating the role of C-RAF.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 656, 20 May 2018, Pages 53-59
Journal: Gene - Volume 656, 20 May 2018, Pages 53-59
نویسندگان
Ying Huang, Xin-Yu Zhang, Su An, Yang Yang, Ying Liu, Qian Hao, Xiao-Xi Guo, Tian-Rui Xu,