Keywords: ADAM; a disintegrin and metalloproteinase; AKT; protein kinase B; APAF 1; apoptotic protease activating factor 1; APC; adenomatous polyposis coli; ATG; autophagy protein; BAK; Bcl 2 homologous antagonist/killer; BAX; Bcl-2 associated -X protein; Bcl-2; B-
مقالات ISI (ترجمه نشده)
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Keywords: APSIM; Agricultural Production Systems Simulator; AFCS; annual forage crop sequences; AP; annual precipitation; BAL; Balcarce; CVAP; coefficient of variation of annual precipitation; CVDM; coefficient of variation of dry matter yield; CVPUE; coefficient o
Keywords: 5-FU; 5-fluorouracil; AF; atrial fibrillation; ALK; anaplastic lymphoma kinase; APD; action potential duration; APL; acute promyelocytic leukemia; BCR-ABL; breakpoint cluster region-Abelson; BTK; Bruton tyrosine kinase; CD20; cluster of differentiation 20
Keywords: α-SMA; α-smooth muscle actin; AIF; apoptosis inducing factor; AP-1; activator protein 1; ARE; antioxidant response element; Bax; Bcl-2 associated X protein; Bcl-2; B-cell lymphoma 2; Bcl-xl; B cell lymphoma extra large; CDKCs; cyclin:CDK complexes; c-My
Keywords: ARSIs; androgen receptor signaling inhibitors; AA; abiraterone acetate; AR; androgen receptor; BPH; benign prostatic hyperplasia; CNV; copy number variation; CRPC; castration resistant prostate cancer; CTC; circulating tumor cells; ctDNA; cell-free circul
Keywords: ALK1; activin receptor-like kinase1; ANG/Ang; angiopoietin; Bcl-xL; b-cell lymphoma-extra large; BM; bone marrow; BMDCs; bone marrow derived cells; BMP; bone morphogenetic protein; Bv8; bombina variagata peptide 8; CAFs; cancer/carcinoma associated fibrob
Keywords: carbonyl reductase 1; tissue distribution; liver; intestine; kidney; LC-MS/MS; protein quantification; proteomics; CBR; carbonyl reductase; DDI; drug-drug interactions; DMF; dimethylformamide; fm; fraction metabolized; IDA; information-dependent acquisiti
Keywords: Liver; Resection; Colorectal; Prognostic; RAS; RAF; Radiomics;
Keywords: 2OHM; 2-hydroxymelatonin; 4OHM; 4-hydroxymelatonin; OS; oxidative stress; FR; free radicals; OIL; OH-inactivating ligand; HOO; hydroperoxyl radical; ROO; peroxyl radicals; DFT; Density Functional Theory; SMD; solvation model based on density; HAT; hydroge
Keywords: Breast cancer; Raf; ERK; Bioinformatics; Kinase inhibitor;
Keywords: BCF; beta cell function; BMI; body mass index; CI; confidence interval; CNG; Centre National de Génotypage; DNA; deoxyribonucleic acid; EDTA; ethylenediaminetetraacetic acid; GEI; gene-environment interaction; GWAS; genome-wide association studies; GRS;
Keywords: in vitro/in vivo correlations (IVIVC); hepatic transport; hepatic metabolism; hepatic clearance; hepatocytes; HIV/AIDS; membrane transport; metabolism; organic anion-transporting polypeptide transporters; APV; amprenavir; ATV; atazanavir; CHO; Chinese h
Keywords: Sheep; Carbon; Water; Land; Energy; Footprint; ABARES; Australian Bureau of Agricultural and Resource Economics and Sciences; CSF; case study farm; dLUC; direct land use change; GHG; greenhouse gas; GWP; global warming potential; NSW HRZ; high rainfall zo
Keywords: AKT; protein kinase B; ATF4; activating transcription factor 4; cAMP; cyclic adenosine monophosphate; CCL5; (C-C motif) ligand 5; CNS; central nervous system; 4EBP1; 4E (elF4E) binding protein; ECM; extracellular matrix; ERK; p44/p42 extracellular signal-
Keywords: Glioblastoma; Treatment; Review; Pharmacology; Targeted therapy; Stem cell; AKT; protein kinase B; BBB; blood-brain barrier; BCNU; carmustin; CCNU; lomustin; c-MET; hepatocyte growth factor receptor; EGF(R); epidermal growth factor (receptor); EGFRvIII; e
Keywords: AP-1; activator protein 1; Dusp; dual-specificity phosphatase; Egr1; early growth response protein 1; ERK; extracellular signal regulated kinase; F2-KO mice; flotillin-2 knockout mice; Flot-1; flotillin-1; Flot-2; flotillin-2; HB-EGF; Heparin Binding-EGF;
Keywords: 0D; zero-dimensional; 1D; one-dimensional; 2D; two-dimensional; AC; alternating current; aCGNTs; aligned catalytically grown nanotubes; AFM; atomic force microscope; AGNTs; arc-grown nanotubes; APTS; 3-aminopropyltriethoxysilane; n; Avrami exponent; CNFs;
Keywords: S/B; signal to background; PDGFR; platelet-derived growth factor receptor; BTK; Bruton's tyrosine kinase; EGFR; epidermal growth factor receptor; HER-2; human epidermal growth factor 2; AMPK; AMP activated protein kinase; BMPR; bone morphogenetic protei
Keywords: AA; acetic acid; CCCP; carbonyl cyanide m-chlorophenylhydrazone; cyt c; cytochrome c; DCF; dichlorophluoresceine; GLU; glucose-grown; H2DCH-DA; 2,7-dihydrodichlorofluorescein diacetate; NAC; N-acetyl cysteine; PCD; programmed cell death; RAF; raffinose-gr
The functions of cucumber sucrose phosphate synthases 4 (CsSPS4) in carbon metabolism and transport in sucrose- and stachyose-transporting plants
Keywords: ADPG; ADP-glucose; F6P; fructose-6-phophate; FBP; fructose-1,6-bisphosphate; Fru; fructose; G1P; glucose-1-phophate; G6P; glucose-6-phophate; Galac; galactinol; Glu; glucose; GolS; galactinol synthase; IC; intermediate cell; MC; mesophyll cell; Myo-iso; m
Proteins involved in the antioxidant and inflammatory response in rutin-treated human skin fibroblasts exposed to UVA or UVB irradiation
Keywords: AKT; protein kinase B; AMBIC; ammonium bicarbonate; Bad; Bcl-2-associated death promoter; Bax; bcl-2-like protein 4; Bcl-2; B-cell lymphoma 2 protein; Bcl-XL; B-cell lymphoma-extra-large protein; CCAR2; cell cycle/apoptosis regulator protein 2; DFF; DNA f
The Transcription Factor ETV5 Mediates BRAFV600E-Induced Proliferation and TWIST1 Expression in Papillary Thyroid Cancer Cells
Keywords: AKT; protein kinase B (or PKB); ATC; anaplastic thyroid carcinoma; BRAF; v-Raf murine sarcoma viral oncogene homolog B (or B-RAF); EMT; epithelial-mesenchymal transition; ERK; extracellular signal-regulated kinase (or mitogen-activated protein kinase 1);
C-RAF function at the genome-wide transcriptome level: A systematic view
Keywords: RAF; rapidly accelerated fibrosarcoma; MAPK; mitogen-activated protein kinase; EGF; epidermal growth factor; MEK; mitogen-activated protein kinase kinase; MST-2; mammalian STE20-like protein kinase 2; ASK-1; apoptosis signal-regulating kinase 1; HTLV-I; h
Isolation and characterization of a Raf gene from Chinese shrimp Fenneropenaeus chinensis in response to white spot syndrome virus infection
Keywords: Raf; Fenneropenaeus chinensis; White spot syndrome virus (WSSV); Expression; SNP;
Influence of silibinin and β-β-dimethylacrylshikonin on chordoma cells
Keywords: Chordoma; β-β-dimethylacrylshikonin; Silibinin; Apoptosis; ACTB; actin beta; AKT; AKT serine/threonine kinase; BAD; BCL2 associated agonist of cell death; BAK; BCL2 antagonist/killer; BAX; BCL2 associated X protein; BCL-2; B cell leukemia/lymphoma 2; BH
DA-Raf, a dominant-negative antagonist of the Ras-ERK pathway, is a putative tumor suppressor
Keywords: Ras-ERK pathway; Raf; Alternative splicing; Transformation; Tumorigenesis; Tumor suppressor;
A cellular threshold for active ERK1/2 levels determines Raf/MEK/ERK-mediated growth arrest versus death responses
Keywords: 4-HT; 4-hydroxytamoxifen; CD; common docking; ERK; extracellular signal-regulated kinase; FRS; F-site recruitment site; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; MEK; mitogen-activated protein kinase kinase; MTT; 3-(4,5-dimethyl-2-thiazolyl)-2,5-di
Cloning, genetic engineering and characterization of TMOF expressed in Saccharomyces cerevisiae to control larval mosquitoes
Keywords: Bti; B. thuringiensis subsp. israelensis; (DPAR)4; a TMOF analogous; GAL; galactose; gfp; Green Fluorescent Protein gene; GFP; green fluorescent protein; his; histidine gene; HSE; heat shock elements; Ig; immunoglobulins; LB; Luria-Bertani plates; Leu; Le
Recent advances of RAF (rapidly accelerated fibrosarcoma) inhibitors as anti-cancer agents
Keywords: MAPK; RAF inhibitors; Anti-cancer agents; Abl; Abelson murine leukemia viral oncogene; ATP; Adenine triphosphate; Bcl-2; B-cell lymphoma; CNS; Central nervous system; COX-2; Cyclo-oxygenase enzyme-2; CR; Conserved region; CRD; Cysteine-rich domain; DFG; A
Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors
Keywords: MAPK; RAF; Kinase;
Oncogenic mutations of PIK3CA and HRAS in carcinoma of cervix in South Indian women
Keywords: Oncogenic mutations; Cervical cancer; Peripheral blood; PCR-CTPP method; PIK3CA; Phosphatidylinositol-4,5-Bisphosphate; 3-Kinase Catalytic Subunit Alpha; HRAS; Harvey rat sarcoma viral oncogene homolog; EGF; Epidermal Growth Factor; PDGF; Platelet Derived
Phenformin Enhances the Efficacy of ERK Inhibition in NF1-Mutant Melanoma
Keywords: AMPK; AMP-activated kinase; BRAFi; BRAF inhibitor; ERK; extracellular signal-regulated kinase; ERKi; ERK inhibitor; PGC1α; peroxisome proliferator-activated receptor gamma, coactivator 1-α; MEK; MAPK/ERK kinase; MEKi; MEK inhibitor; mTOR; mechanistic ta
Optogenetics - Bringing light into the darkness of mammalian signal transduction
Keywords: AsLOV2; Avena sativa light-oxygen-voltage domain 2; ChR2; Channelrhodopsin-2; CIB1; Chryptochrome-interacting basic helix-loop-helix 1; CIBN; N-terminus of CIB1; COP1; Constitutive photomorphogenesis protein 1; CPH1; Cyanobacterial phytochrome 1; CRY2; Cr
Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence
Keywords: AD; Alzheimer's Disease;; AGEs; advanced glycation endproducts; ALP; autophagy-lysosome pathway; ARF; alternate reading frame; ATGs; autophagy-related proteins; BAG3; Bcl2-associated athanogene 3; Bcl-2; B-cell lymphoma 2; BrdU; 5-bromodeoxyuridine;; CMA;
Targeting mutant NRAS signaling pathways in melanoma
Keywords: Melanoma; NRAS; RAF; PI3K; Ral GEF; Targeted inhibitors;
Role of 3â² repressor sequences of p53 in anti-cancer drug sensitivity of human lung tumor cells
Keywords: NVB; navelbine; PDD; cisplatin; 5FU; 5-fluorouracil; MDM2; mouse double minute 2 homolog; miRNA; microRNAs; lncmRNA; long non-coding mRNAs; p53(wt); full-length p53; p53(del); the deleted-C-terminal p53; ANOVA; analysis of variance; Ad; adenovirus; MOI; m
The role of epsilon PKC in acute and chronic diseases: Possible pharmacological implications of its modulators
Keywords: PKC; protein kinase C; IPC; ischemic pre conditioning; RACK; receptor for activated C-kinase; DAG; diacylglycerol; beta COP; coatomer subunit beta; CHOK1; chinese hamster ovary K1; CVD; cardiovascular disease; mKATP; ATP-sensitive mitochondrial potassium
Wildtype adult stem cells, unlike tumor cells, are resistant to cellular damages in Drosophila
Keywords: Stem cell; Apoptosis; Autophagy; Tumorigenesis; Drosophila; Raf; Mitochondria;
A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling
Keywords: MAPK; PI3K; RAF; RAS; RAS-binding domain; rigosertib
Design and synthesis of new potent anticancer benzothiazole amides and ureas featuring pyridylamide moiety and possessing dual B-RafV600E and C-Raf kinase inhibitory activities
Keywords: Anticancer activity; Benzothiazole; Urea; Amide; Pyridylamide; B-RafV600E; C-Raf; ATCC; American tissue culture collection; CDI; 1,1'-carbonyldiimidazole; CLogP; Calculated LogP (Partition coefficient); DIPEA; N,N-diisopropylethylamine; DTT; Dithiothreito
In vitro metabolism of l-corydalmine, a potent analgesic drug, in human, cynomolgus monkey, beagle dog, rat and mouse liver microsomes
Keywords: l-Corydalmine; Metabolism; Hepatic microsomes; Cytochrome P450s; Interspecies difference; CyLM; cynomolgus monkey liver microsomes; CYP450; cytochrome P450; DLM; dog liver microsomes; HLM; human liver microsomes; HPLC; high-performance liquid chromatograp
The p21-activated kinase, PAK2, is important in the activation of numerous pancreatic acinar cell signaling cascades and in the onset of early pancreatitis events
Keywords: CCK; COOH-terminal octapeptide of cholecystokinin; TPA; 12-O-tetradecanoylphorbol-13-acetate; PAK; p21-activated kinases; SFK; Src family of kinases; PKC; protein kinase C; PYK2; proline-rich tyrosine kinase 2; FAK; focal adhesion kinase; SHC; Src homolog
Segmental dynamics in hybrid polymer/POSS nanomaterials
Keywords: 6FDA; 2,2â²-bis(3,4-dicarboxyphenyl)-hexafluoropropane dianhydride; AFM; atomic force microscopy; BD; butanediol; BEMA; bisphenol A ethoxylate dimethacrylate; BPTA; benzophenonetetracarboxylic dianhydride; BSA; 4,4â²-(1,3-phenylenediisopropylidene) bisa
Role of the ERK1/2 pathway in tumor chemoresistance and tumor therapy
Keywords: ERK1/2; Ras; Raf; MEK; Tumor chemoresistance; Tumor therapy;
ERK1/2 can feedback-regulate cellular MEK1/2 levels
Keywords: 4-HT; 4-hydroxytamoxifen; ERK; extracellular signal-regulated kinase; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; MEK; mitogen-activated protein kinase kinase; UTR; untranslated region; Raf; MEK1; MEK2; ERK1/2; Feedback regulation;
Incidence and risk of xerosis with targeted anticancer therapies
Keywords: Bcr-Abl; CD20; CD52; dry skin; EGFR; HDAC; HER2; incidence; MEK; mTOR; Raf; risk; xerosis; VEGFRADL, activities of daily living; AE, adverse event; CI, confidence interval; CTCAE, Common Terminology Criteria for Adverse Events; dAE, dermatologic adverse e
GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease
Keywords: 6-OHDA; 6-hydroxy-dopamine; Akt, PKB; protein kinase B, serine/threonine-specific protein kinase; BDNF; brain derived neurotrophic factor; CaMKIIβ; calcium-calmodulin-dependent protein kinase II β isoform; cAMP; 3â²,5â²-cyclic adenosine monophosphate;
RAF signaling in neuroendocrine neoplasms: From bench to bedside
Keywords: RAF; RAF-1; BRAF; MAPK; Neuroendocrine tumors; Neuroendocrine neoplasms; NET; Molecular targeted therapy; Cell signaling;
microRNA-340 as a modulator of RAS–RAF–MAPK signaling in melanoma
Keywords: microRNA; miR-340; Melanoma; Tumor suppressor; Proliferation; Invasion; RAS; RAF; MAPK
Nuclear magnetic resonance analysis of water soluble metabolites allows the geographic discrimination of pistachios (Pistacia vera)
Keywords: Ac; acetic acid; ADE; adenosine; ATP; adenosine-5â²-triphosphate; ALA; alanine; ALL; allantoin; AA; ascorbic acid; ARG; arginine; ASN; asparagine; ASP; aspartate; CA; citric acid; CHN; choline; CRE; creatine; CR; creatinine; DDZ; daidzein; EtLAC; ethyl-l