“RAF” neighborhood: Protein-protein interaction in the Raf/Mek/Erk pathway
Keywords: Ras; Raf; Mek; Erk; Protein-protein interaction; Kinase inhibitor; Cancer therapy;
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Cholesterol reducing and bile-acid binding properties of taioba (Xanthosoma sagittifolium) leaf in rats fed a high-fat diet
Keywords: BA; bile acid; CEL; cellulose; CNCD; chronic non-communicable diseases; CYP7A1; cholesterol 7α-hydroxylase; FER; feed efficiency ratio; FFM; fat-free mass; INU; inulin; LCEL; low cellulose; LTL; lyophilised taioba leaf; RAF; relative abdominal fat; SCFA;
Regulatory mechanisms for glycogenolysis and K+ uptake in brain astrocytes
Keywords: AE; anion exchanger; AMPK; AMP-activated protein kinase; CA; carbonic anhydrase; CTS; cardiotonic steroids; DAB; 1,4-dideoxy-1,4-imino-d-arabinitol; DIDS; 4,4â²-diisothiocyanostilbene-2,2â²-disulfonic acid; EGFR; epidermal growth factor receptor; ERK; e
Combined CpG and poly I:C stimulation of monocytes results in unique signaling activation not observed with the individual ligands
Keywords: TLRs; Toll-like receptors; CpG; unmethylated CpG oligodeoxynucleotides; poly I:C; polyinosinic-polycytidylic acid; NO; nitric oxide; iNOS; inducible nitric oxide synthase; CREB; cAMP response element-binding protein; NFκB; nuclear factor κB; PRRs; pat
Utility of nettle (Urtica dioica) in layer diets as a natural yellow colorant for egg yolk
Keywords: ADFI; average daily feed intake; ADFom; acid detergent fiber exclusive of residual ash; AIA; acid insoluble ash; aNDFom; neutral detergent fiber assayed with a heat stable amylase and exclusive of residual ash; ME; metabolizable energy; RAF; Rancimat anti
RAF and antioxidants prevent cell death induction after growth factor abrogation through regulation of Bcl-2 proteins
Keywords: RAF; Antioxidants; Reactive oxygen species (ROS); Mitochondria; Bcl-2 proteins; Apoptosis;
MEK-1 activates C-Raf through a Ras-independent mechanism
Keywords: Raf; Ras; MEK; ERK; MAPK; Phosphorylation;
Epidermal hyperplasia induced by Raf-MAPK signaling requires Stat3 activation
Keywords: Epidermal hyperplasia; Raf; Stat3; Transgenic mice; Knockout mice
Exploration of 1-(3-chloro-4-(4-oxo-4H-chromen-2-yl)phenyl)-3-phenylurea derivatives as selective dual inhibitors of Raf1 and JNK1 kinases for anti-tumor treatment
Keywords: Flavones; Aromatic urea; Raf; JNK; Kinases inhibitors; Hepatocellular carcinoma
Pruritus in patients treated with targeted cancer therapies: Systematic review and meta-analysis
Keywords: Bcr-Abl; cancer; CD20; epidermal growth factor receptor; inhibitor; itch; mammalian target of rapamycin; pruritus; Raf; vascular endothelial growth factor receptorAE, adverse events; CD20, B-lymphocyte antigen cluster of differentiation 20; CI, confidence
Signalisation cellulaire et cancer : caractérisation de cibles thérapeutiques
Keywords: Signalisation cellulaire; Cancer; Prolifération cellulaire; Voie des MAP kinases; Récepteurs à activité tyrosine kinase; Protéine RAS; Protéine RAFCell signalling; Cancer; Cell proliferation; MAP kinase pathway; Tyrosine kinase receptors; RAS protein; RAF
Targeting Raf/MEK/ERK pathway in pituitary adenomas
Keywords: Raf; Signalling pathway; Pituitary adenomas
Redox-regulating role of insulin: The essence of insulin effect
Keywords: 4-HNE; 4-hydroxynonenal; 8-OHdG; 8-hydroxydeoxyguanosine; 8-OHG; 8-hydroxyguanine; 8-iso-PGF2α; 8-iso-prostaglandin F2α; AD; Alzheimer's disease; AIDS; acquired immunodeficiency syndrome; Akt; protein kinase B; AMI; acute myocardial infarction; APS; a
Polycystic Liver Diseases: Congenital Disorders of Cholangiocyte Signaling
Keywords: AC; adenyl cyclase; AC6; adenylyl-cyclases-6; ADPKD; autosomal-dominant polycystic kidney disease; AKT; v-akt murine thymoma viral oncogene homolog 1; ARPKD; autosomal-recessive polycystic kidney disease; cAMP; cycle adenosine monophosphate; CD; Caroli di
Iron bioavailability from ferric pyrophosphate in rats fed with fructan-containing yacon (Smallanthus sonchifolius) flour
Keywords: YF; yacon flour; RAF; Raftilose P95; FS; ferrous sulphate; FP; ferric pyrophosphate; ITF; inulin-type fructans; FOS; fructooligosaccharides; HRE; Hb repletion efficiency; RBV; relative biological value; SCFA; short-chain fatty acids; Iron bioavailability;
The Raf/MEK/extracellular signal-regulated kinase 1/2 pathway can mediate growth inhibitory and differentiation signaling via androgen receptor downregulation in prostate cancer cells
Keywords: AR; androgen receptor; c.s.FBS; charcoal/dextran-stripped fetal bovine serum; ERK; extracellular signal-regulated kinase; MEK; mitogen activated protein kinase kinase; NEP; neutral endopeptidase; NSE; neuron specific enolase; PCa; prostate cancer; PSA; pr
Molecular networks in respiratory epithelium carcinomas
Keywords: Respiratory epithelium carcinomas; EGFR; Ras; Raf; MAPK; PI3K; Akt; JAK; STAT; PLC; PKC
Coupling cellular mitogenesis to apoptosis by designed biomolecules
Keywords: Signaling rewiring; Ras; Raf; Caspase 3; Mitogenesis; Apoptosis;
Myricetin suppresses UVB-induced wrinkle formation and MMP-9 expression by inhibiting Raf
Keywords: Myricetin; Anti-wrinkle; Raf; Photoaging; UVB
The CRAL/TRIO and GOLD domain protein TAP-1 regulates RAF-1 activation
Keywords: RBD, Ras binding domain; GOLD, Golgi dynamics; CRAL/TRIO, cellular retinaldehyde and TRIO domain; TAP, tocopherol associated protein; CGR-1, CRAL/TRIO and GOLD domain suppressor of activated RasRas signaling pathway; Raf; CRAL/TRIO; GOLD; TAP-1; CGR-1; Ca
The subcellular localization of MEK and ERK—A novel nuclear translocation signal (NTS) paves a way to the nucleus
Keywords: Signaling pathways; MAPK cascades; ERK; MEK; Raf
Neutrophil-dominant psoriasis-like skin inflammation induced by epidermal-specific expression of Raf in mice
Keywords: Raf; Skin inflammation; Neutrophil; Transgenic mice; Psoriasis
Erratum to “Neutrophil-dominant psoriasis-like skin inflammation induced by epidermal-specific expression of Raf in mice” [J. Dermatol. Sci. 58 (2010) 28–35]
Keywords: Raf; Skin inflammation; Neutrophil; Transgenic mice; Psoriasis
Molecular characterisation of MEK1/2- and MKK3/6-like mitogen-activated protein kinase kinases (MAPKK) from the fox tapeworm Echinococcus multilocularis
Keywords: Echinococcus; Cestode; Parasite; MAP kinase cascade; MEK1; MKK3; 14-3-3; Raf;
Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds
Keywords: WKFRHTGMVITXBX-UHFFFAOYSA-N; Boc; tert-butoxycarbonyl; BRAF; V-RAF murine sarcoma viral oncogene homolog B1; DCM; dichloromethane; DMF; dimethylformamide; ERK; extracellular regulated kinase; MAPK; mitogen-activated protein kinase; MEK; MAPK/ERK kinase; M
Discovery of highly potent and selective type I B-Raf kinase inhibitors
Keywords: B-Raf; Kinase; Inhibitors; RAS; Raf
Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors
Keywords: Raf; Kinase; Inhibitor; Pyrazolo[1,5-a]pyrimidine
Development of monoclonal antibodies for detection of Antisecretory Factor activity in human plasma
Keywords: AF; Antisecretory Factor; rAF; recombinant expressed AF; SPC; specially processed cereals; PBS; phosphate buffered saline; SDS-PAGE; sodium dodecyl sulfate-poly acryl amide gel electrophoresis; ELISA; enzyme-linked immunosorbent assay; AP; alkaline phosph
Molecular Biology of Renal Cortical Tumors
Keywords: HIF; VEGF; Raf; mTOR; Therapy; VHL
Study of crystallinity and thermomechanical analysis of annealed poly(ethylene terephthalate) films
Keywords: Poly(ethylene terephthalate); MAF; RAF; Crystallinity; Glass transition temperature; Thermomechanical analysis
Receptor-mediated tobacco toxicity: Alterations of the NF-κB expression and activity downstream of α7 nicotinic receptor in oral keratinocytes
Keywords: Nicotinic acetylcholine receptors; Gene expression; NF-κB; Ras; Raf; ERK; MEK
Inhibitors of Raf kinase and MEK signaling
Keywords: Target; RAS; RAF; MEK; ERK; Signal; Transduction; Inhibitors
An intrinsic ATPase activity of phospho-MEK-1 uncoupled from downstream ERK phosphorylation
Keywords: MAPK signal transduction; MEK; Raf; ERK; Intrinsic ATPase; Kinase; Inhibitor; Screening assay;
The integration of signaling by multiprotein complexes containing Raf kinases
Keywords: Raf; MAPK; MLK3; NF2/merlin; Mst2/Hippo; Cell proliferation
Could simulated emergency procedures practised in a static environment improve the clinical performance of a Critical Care Air Support Team (CCAST)?: A literature review
Keywords: Critical care; Simulation training; Improved clinical performance; RAF; Aeromedical evacuation
Activated Ras induces cytoplasmic vacuolation and non-apoptotic death in glioblastoma cells via novel effector pathways
Keywords: Ras; Non-apoptotic cell death; Vacuoles; Glioblastoma; Raf; PI 3-Kinase; Farnesylation; Autophagy;
Protein kinase Cε makes the life and death decision
Keywords: Apoptosis; PKCε; Akt; Ras; Raf; MAPK; Bcl-2; Bid;
c-jun amino-terminal kinase and mitogen activated protein kinase 1/2 mediate hepatocyte growth factor-induced migration of brain endothelial cells
Keywords: HGF; Brain; Endothelial cells; Migration; JNK; ERK; Pyk-2; Src; Raf; MEK
Raf kinases: Function, regulation and role in human cancer
Keywords: Raf; Phosphorylation; Cancer; MAPK; Ras
Molecular genetics and targeted therapies for cutaneous melanoma
Keywords: Melanoma; Signal transduction; RAF; MEK; Akt; VEGF; CDK
Ran binding protein 9 interacts with Raf kinase but does not contribute to downstream ERK1/2 activation in skeletal myoblasts
Keywords: Myogenesis; Raf; ERK1/2; Inhibition; RanBP9; MEK1; Skeletal muscle
14-3-3 proteins as potential oncogenes
Keywords: 14-3-3; Raf; Cell-cycle; Mitogenesis; Cancer
Molecular profile of hyalinizing trabecular tumours of the thyroid: High prevalence of RET/PTC rearrangements and absence of B-raf and N-ras point mutations
Keywords: Thyroid; Oncogene; Kinase; RAF; RET; Papillary carcinoma;
Identification of coumarin derivatives as a novel class of allosteric MEK1 inhibitors
Keywords: MEK1; Coumarins; Allosteric Inhibitors; TR-FRET; COT; RAF
Second nature: Biological functions of the Raf-1 “kinase”
Keywords: Raf; Kinase; Knock-out; Survival; Motility
Sorafenib: Scientific Rationales for Single-Agent and Combination Therapy in Clear-Cell Renal Cell Carcinoma
Keywords: Multiple-kinase inhibitors; Platelet-derived growth factor; Raf; Vascular endothelial growth factor;
Distinct signaling pathways for induction of type II NOS by IFNγ and LPS in BV-2 microglial cells
Keywords: BSA; bovine serum albumin; CNS; central nervous system; DMEM; Dulbecco's Modified Eagle Medium; ERK; extracellular signal-regulated kinase; GAS; interferon-γ-activated site; IFN; interferon; IκB; NF-κB inhibitory protein; JAK; Janus kinase; LPS; lipopo
The link between rigid amorphous fraction and crystal perfection in cold-crystallized poly(ethylene terephthalate)
Keywords: Poly(ethylene terephthalate); Rigid amorphous fraction; RAF;
Molecular cloning and characterization of Ras- and Raf-homologues from the fox-tapeworm Echinococcus multilocularis
Keywords: bp; base pairs; CRD; cysteine-rich domain; CR; conserved region; EGF; epidermal growth factor; GAP; GTPase activating protein; GEF; guanine nucleotide exchange factor; MAP; mitogen activated protein; RACE; rapid amplification of cDNA ends; RBD; Ras-bindin
Modulation of the glutamatergic receptors (AMPA and NMDA) and of glutamate vesicular transporter 2 in the rat facial nucleus after axotomy
Keywords: excitatory amino acids; motor neuron section; PSD95; beta catenin; cadherin; tetrodotoxin; AF; arithmetic fluorescence; AMPAR; α-amino-3-hydroxi-5-methylisoxazole-4-propionic acid receptor; Cy3; cyanine 3; MVN; medial vestibular nucleus; NMDAR; N-methyl-