کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8645329 | 1569782 | 2018 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The association of 22 Y chromosome short tandem repeat loci with initiative-aggressive behavior
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کلمات کلیدی
ESRCatechol-O-methyltransferaseDBHCOMTTphMAOAY-STRsShort tandem repeats - تداوم کوتاه مدتCase–control study - مطالعه موردی شاهدmonoamine oxidase A - مونوآمین اکسیداز Atryptophan hydroxylase - هیدروکسیلاز تریپتوفانGenetic polymorphism - پلیمورفیسم ژنتیکیY chromosome - کروموزوم YAndrogen Receptor - گیرنده آندروژنیEstrogen receptor - گیرنده استروژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
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چکیده انگلیسی
Aggressive behavior represents an important public concern and a clinical challenge to behaviorists and psychiatrists. Aggression in humans is known to have an important genetic basis, so to investigate the association of Y chromosome short tandem repeat (Y-STR) loci with initiative-aggressive behavior, we compared allelic and haplotypic distributions of 22 Y-STRs in a group of Chinese males convicted of premeditated extremely violent crimes (nâ¯=â¯271) with a normal control group (nâ¯=â¯492). Allelic distributions of DYS533 and DYS437 loci differed significantly between the two groups (Pâ¯<â¯0.05). The case group had higher frequencies of DYS533 allele 14, DYS437 allele 14, and haplotypes 11-14 of DYS533-DYS437 compared with the control group. Additionally, the DYS437 allele 15 frequency was significantly lower in cases than controls. No frequency differences were observed in the other 20 Y-STR loci between these two groups. Our results indicate a genetic role for Y-STR loci in the development of initiative aggression in non-psychiatric subjects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 654, 15 May 2018, Pages 10-13
Journal: Gene - Volume 654, 15 May 2018, Pages 10-13
نویسندگان
Chun Yang, Huajie Ba, Wei Zhang, Shuyou Zhang, Hanqing Zhao, Haiying Yu, Zhiqin Gao, Binbin Wang,