Polymorphism rs2476601 in the PTPN22 gene is associated with type 1 diabetes in children from the South Region of Brazil

- PTPN22 is the third major genetic locus that contributes to the risk of development of T1D.
- PTPN22 is involved in the regulation of innate and adaptive immune responses.
- R620W (rs2476601) is associated with increased risk for T1D.