کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8645820 | 1569793 | 2018 | 34 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Genome-wide mining of perfect microsatellites and tetranucleotide orthologous microsatellites estimates in six primate species
ترجمه فارسی عنوان
استخراج ژنوم کامل میکروسلائیت ها و میکروسکابل های ارتوکلوتید در شش گونه پریمات
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کلمات کلیدی
MicrocebusSSRsMicrocebus murinusChrHomo - انسان، هوموTetranucleotide - تترانوکلئوتیدTrinucleotide - ترنوکوئوتیدgenome-wide - در سراسر ژنومSimple sequence repeats - دنباله ساده تکرار می شودDinucleotide - دینوکلئوتیدMicrosatellite - ریزماهوارهMacaca mulatta - ماتاکت مککاPAN - ماهی تابهMononucleotide - مونونوکلئوتیدaverage - میانگینMacaca - میمونHomo sapiens - نام علمی انسانPrimate - نخستیسانان، نخستیها، پریمات هاPapio - پاپیوPapio anubis - پاپیو آنوبیسPan troglodytes - پت troglodytesChromosome - کروموزم
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
چکیده انگلیسی
Advancement in genome sequencing and in silico mining tools have provided new opportunities for comparative primate genomics of microsatellites. The SSRs (simple sequence repeats) numbers were not correlated with the genome size (Pearson, r = 0.310, p = 0.550), and were positively correlated with the total length of SSRs (Pearson, r = 0.992, p = 0.00). A total of 224,289 tetranucleotide orthologous microsatellites families and 367 single-copy orthologous SSRs loci were found in six primate species by homologous alignment. The inner mutation types of single-copy orthologous SSRs loci included the copy number variance, point mutation, and chromosomal translocation. The accumulated repeat times and average length of tetranucleotide orthologous microsatellites in Rhinopithecus roxellana, Papio anubis and Macaca mulatta were longer than Homo sapiens and Pan troglodytes, which showed the tetranucleotide orthologous SSRs loci had more repeat times and longer average length on the branches with earlier divergence time, one exception may be Microcebus murinus as a primitive monkey with a smallest morphology in Malagasy. Our conclusion indicated that single-copy tetranucleotide orthologous SSRs sequences accumulated individual mutation more slowly through time in H. sapiens and P. troglodytes than in R. roxellanae, P. anubis and M. mulatta. However, such divergence wouldn't arise uniformly in all branches of the primate tree. A comparison of genomic sequence assemblages would offer remarkable insights about comparisons and contrasts, and the evolutionary processes of the microsatellites involved in human and nonhuman primate species.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 643, 15 February 2018, Pages 124-132
Journal: Gene - Volume 643, 15 February 2018, Pages 124-132
نویسندگان
Yongtao Xu, Wujiao Li, Zongxiu Hu, Tao Zeng, Yongmei Shen, Sanxu Liu, Xiuyue Zhang, Jing Li, Bisong Yue,