کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8646133 | 1569796 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
High bone marrow miR-19b level predicts poor prognosis and disease recurrence in de novo acute myeloid leukemia
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کلمات کلیدی
CN-AMLAMLmiR-19RQ-PCRROCHRMAAUC - AUCHCC - HCCoverall survival - بقای کلhigh-resolution melting analysis - تجزیه و تحلیل ذوب با وضوح بالاcomplete remission - رمی کاملreal-time quantitative PCR - زمان واقعی PCR کمیFab - فابFrench-American-British - فرانسوی-آمریکایی-انگلیسیacute myeloid leukemia - لوسمی حاد میلوئیدی یا به اختصار AMLAcute myeloid leukemia (AML) - لوسمی میلوئید حاد (AML)bone marrow - مغز استخوانarea under the ROC curve - منطقه تحت منحنی ROCprognosis - پیش شناخت بیماریHepatocellular carcinoma - کارسینوم هپاتوسلولار(کارسینوم سلولهای استخوانی)receiver operating characteristic - گیرنده عامل عامل
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Oncogenic role of miR-19 family has been identified in human cancers especially in lymphoid malignancies. However, to date, little studies investigated the role of miR-19 family in myeloid malignancies. Herein, we examined miR-19a/b expression and explored its clinical significance in de novo acute myeloid leukemia (AML). The detection of miR-19a/b expression was performed by real-time quantitative PCR in bone marrow mononuclear cells of 113 patients and 42 healthy donors. Both miR-19a/b levels were significantly increased in AML patients in contrast to controls. Patients with miR-19a/b overexpression were more frequently occurred in female, and had an older age. Moreover, cases with miR-19a overexpression had a higher frequency of U2AF1, C-KIT and CEBPA mutations, whereas miR-19b overexpressed cases harbored U2AF1 and IDH1/2 mutations. There was no significant association of miR-19a overexpression with complete remission (CR) rate and overall survival (OS) among whole-cohort AML, non-M3 AML, and cytogenetically normal AML (CN-AML). However, although miR-19b overexpression was not correlated with CR rate, patients with miR-19b overexpression presented significantly shorter OS in whole-cohort AML and a trend in non-M3 AML and CN-AML patients. Importantly, our data also showed that miR-19a/b expression level at CR phase was lower than diagnosis time, and was returned to primary level even higher when at relapse phase. Our findings revealed that miR-19a/b overexpression were frequent events in de novo AML patients. Moreover, up-regulation of miR-19b expression was associated with poor prognosis and disease recurrence in AML.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 640, 15 January 2018, Pages 79-85
Journal: Gene - Volume 640, 15 January 2018, Pages 79-85
نویسندگان
Ting-juan Zhang, Jiang Lin, Jing-dong Zhou, Xi-xi Li, Wei Zhang, Hong Guo, Zi-jun Xu, Yang Yan, Ji-chun Ma, Jun Qian,