کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8648399 1570692 2018 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
CD8+CD28+ T cells might mediate injury of cardiomyocytes in acute myocardial infarction
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
CD8+CD28+ T cells might mediate injury of cardiomyocytes in acute myocardial infarction
چکیده انگلیسی
CD8+ T cells accumulate in the necrotic myocardium of acute myocardial infarction (AMI). It is unclear whether CD8+CD28+ T cells, a specific subset of CD8+ T cells, contribute to myocardial injury. In this study, 92 consecutive patients with AMI and 28 healthy control subjects were enrolled. The frequency of CD8+CD28+ T cells in peripheral blood samples was assayed by flow cytometry. Plasma cardiac troponin I (TNI) and left ventricular ejection fraction (LVEF) were determined. Long-term prognosis of the patients was evaluated by major adverse cardiac and cerebrovascular events (MACCE) over a 12-month follow-up period. Our findings indicated that patients with AMI who presented with high numbers of CD8+CD28+ T cells had an increased infarction size and aggravated ventricular function. We proposed that cytotoxic CD8+CD28+ T cell-mediated myocardial necrosis may act as a novel and alternative pathway of AMI.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 101, September 2018, Pages 74-79
نویسندگان
, , , , ,