کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8649989 | 1571073 | 2018 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inhibition of neuronal nitric oxide synthase attenuate the hypothermic effect of ketamine-magnesium sulfate combination in rats
ترجمه فارسی عنوان
مهار سنتاز اکسید نیتریک عصبی کاهش اثر هیپوترمی ترکیب کتامین و منیزیم سولفات در موش صحرایی
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کلمات کلیدی
کتامین، منیزیم، عصبی اکسید نیتریک، موش
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی
Ketamine and magnesium as NMDA receptor antagonists interact synergistically to decrease body temperature in rats. The mechanism of the hypothermic effect of the ketamine-magnesium sulfate combination has not been studied until now. The aim of this study was to examine whether nitric oxide (NO) has a role in the hypothermic effect of ketamine (10â¯mg/kg) and the combination of ketamine (5â¯mg/kg) and magnesium sulfate (5â¯mg/kg). The body temperature was measured by insertion of a thermometer probe 5â¯cm into the colon of unrestrained male Wistar rats (200-250â¯g). N(Ï)-nitro-L-arginine methyl ester (L-NAME 2.5 and 5â¯mg/kg) as non-selective inhibitor of nitric oxide synthase at a dose of 5â¯mg/kg antagonized the effect of the ketamine-magnesium sulfate combination at 60â¯min (pâ¯<â¯0.05) and 90â¯min (pâ¯<â¯0.01). Ketamine induced hypothermia was not affected by administrating of L-NAME (2.5 and 5â¯mg/kg). Inhibitor of inducible nitric oxide synthase N6-(1-Iminoethyl)-L-lysine hydrochloride (L-NIL 1.25â¯mg/kg and 2.5â¯mg/kg, sc) did not significantly change the hypothermic response evoked by the ketamine-magnesium sulfate combination. Inhibitor of neuronal nitric oxide synthase N-Ï-Propyl-L-arginine hydrochloride (L-NPA) at a dose of 2â¯mg/kg antagonized the combination at 60â¯min when it achieved the maximum effect. The NO pathway is not involved in the hypothermic effect of ketamine. Production of NO through neuronal NO synthase, might play a role in the mechanism of the hypothermic effect of the ketamine-magnesium sulfate combination.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Thermal Biology - Volume 74, May 2018, Pages 1-5
Journal: Journal of Thermal Biology - Volume 74, May 2018, Pages 1-5
نویسندگان
Katarina SaviÄ VujoviÄ, Sonja VuÄkoviÄ, Aleksandar ÄuroviÄ, NebojÅ¡a Nick KneževiÄ, Milica Prostran,