کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8650599 | 1571131 | 2018 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Severity-dependent influence of isocapnic hypoxia on reaction time is independent of neurovascular coupling
ترجمه فارسی عنوان
تأثیر وابسته به شدت وابستگی هیپوکسی ایزوکانیک به زمان واکنش مستقل از همبستگی عصبی و عصبی است
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کلمات کلیدی
جریان خون مغزی، هیپوکسیا، شناخت عصبی، اتصال عصبی عضلانی، زمان پاسخ،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
فیزیولوژی
چکیده انگلیسی
With exposure to acute normobaric hypoxia, global cerebral oxygen delivery is maintained via increases in cerebral blood flow (CBF); therefore, regional and localized changes in oxygen tension may explain neurocognitive impairment. Neurovascular coupling (NVC) is the close temporal and regional relationship of CBF to changes in neural activity and may aid in explaining the localized CBF response with cognitive activation. High-altitude related cognitive impairment is likely affected by hypocapnic cerebral vasoconstriction that may influence regional CBF regulation independent of hypoxia. We assessed neurocognition and NVC following 30â¯min of acute exposure to isocapnic hypoxia (decreased partial pressure of end-tidal oxygen; PETO2) during moderate hypoxia (MOD HX; 55â¯mmâ¯Hg PETO2), and severe hypoxia (SEV HX; 45â¯mmâ¯Hg PETO2) in 10 healthy individuals (25.5â¯Â±â¯3.3â¯yrs). Transcranial Doppler ultrasound was used to assess mean posterior and middle cerebral blood velocity (PCAv and MCAv, respectively) and neurocognitive performance was assessed via validated computerized tests. The main finding was that reaction time (i.e., kinesthetic and visual-motor ability via Stroop test) was selectively impaired in SEV HX (â4.6â¯Â±â¯5.2%, Pâ¯=â¯0.04), but not MOD HX, while complex cognitive performance (e.g., psychomotor speed, cognitive flexibility, processing speed, executive function, and motor speed) was unaffected with hypoxia (Pâ¯>â¯0.05). Additionally, severity of hypoxia had no effect on NVC (PCAv CON vs. SEV HX relative peak response 13.7â¯Â±â¯6.4% vs. 16.2â¯Â±â¯11.5%, Pâ¯=â¯0.71, respectively). In summary, severe isocapnic hypoxia impaired reaction time, but not complex cognitive performance or NVC. These findings have implications for recreational and military personnel who may experience acute hypoxia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 188, 1 May 2018, Pages 262-269
Journal: Physiology & Behavior - Volume 188, 1 May 2018, Pages 262-269
نویسندگان
Hannah G. Caldwell, Geoff B. Coombs, Michael M. Tymko, Daniela Nowak-Flück, Philip N. Ainslie,