کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8662040 1576086 2018 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Serum irisin levels are associated with adverse cardiovascular outcomes in patients with acute myocardial infarction
ترجمه فارسی عنوان
سطوح سرمی آریزین با پیامدهای نامطلوب قلبی عروقی در بیماران مبتلا به انفارکتوس حاد قلب ارتباط دارد
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی
Irisin, a recently identified myokine, regulates mitochondrial function and energy expenditure. The concentration of irisin is significantly altered after ST-elevation myocardial infarction (STEMI). We hypothesized that serum irisin concentration is associated with adverse cardiovascular outcomes after myocardial infarction. Serum irisin concentrations were measured using enzyme-linked immunosorbent assay (ELISA) in 399 patients 28 d after the onset of STEMI in a prospective single-center cohort study. We assessed the association between irisin concentrations and adverse cardiovascular events during a 3-year follow-up. The excess risks of cardiovascular mortality, stroke, heart failure, and revascularization were predominantly seen among those with the highest concentrations of irisin, with concentrations higher than 75th percentile of the overall distribution had a ~ 4-fold increase in risk (hazard ratio = 3.96, 95% confidence interval 1.55 to 10.11, P < 0.01). Our findings showed that serum concentrations of irisin are elevated in post-STEMI patients with increased risk for adverse cardiovascular events. Novel therapies targeting irisin may represent a new direction in the treatment of STEMI.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 261, 15 June 2018, Pages 12-17
نویسندگان
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