کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8667430 | 1577998 | 2018 | 37 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Significant interaction of hypertension and homocysteine on neurological severity in first-ever ischemic stroke patients
ترجمه فارسی عنوان
تعامل قابل توجهی از فشار خون بالا و هموسیستئین بر شدت عصبی در بیماران مبتلا به سکته مغزی ایسکمیک
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کلمات کلیدی
هموسیستئین، فشار خون، سکته مغزی ایسکمیک، شدت نورولوژیک،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
سیستم های درون ریز و اتونومیک
چکیده انگلیسی
It is not known whether combination of hypertension and high homocysteine (HHcy) impacts on stroke-related neurological severity. Our aim was to determine whether there is an interaction of hypertension and HHcy on neurological severity in first-ever ischemic stroke patients. We analyzed neurological severity among 189 consecutive first-ever ischemic stroke patients with or without hypertension or HHcy. Hypertension (odds ratio [OR]: 8.086, 95% confidence interval [CI]: 3.596-18.181, PÂ <Â .001) and total homocysteine (OR: 1.403, 95% CI: 1.247-1.579, PÂ <Â .001) were independently associated with neurological severity. In receiver-operating characteristic analysis, total homocysteine was a significant predictor of neurological severity (area under curve: 0.794; PÂ <Â .001). A multiplicative interaction of hypertension and HHcy on more severe neurological severity was revealed by binary logistic regression (OR: 13.154, 95% CI: 5.293-32.691, PÂ <Â .001). Analysis further identified a more than multiplicative interaction of hypertension and HHcy on neurological severity compared with patients without each condition (OR: 50.600, 95% CI: 14.775-173.285, PÂ <Â .001). Interaction effect measured on an additive scale showed that 76.4% patients with moderate/severe neurological severity were attributed to interaction of hypertension and HHcy. Significant interaction of hypertension and HHcy on neurological severity was found on multiplicative and additive scale in first-ever Chinese ischemic stroke patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Society of Hypertension - Volume 12, Issue 7, July 2018, Pages 534-541
Journal: Journal of the American Society of Hypertension - Volume 12, Issue 7, July 2018, Pages 534-541
نویسندگان
Ying-Li BSc, Rui BSc, Yi-Fei MD, PhD, Lei BSc, Xi-Xin BSc, Peng BSc, Jian BSc, Ping MD, PhD, Xiao-Shu MD, PhD,