کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8667430 1577998 2018 37 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Significant interaction of hypertension and homocysteine on neurological severity in first-ever ischemic stroke patients
ترجمه فارسی عنوان
تعامل قابل توجهی از فشار خون بالا و هموسیستئین بر شدت عصبی در بیماران مبتلا به سکته مغزی ایسکمیک
کلمات کلیدی
هموسیستئین، فشار خون، سکته مغزی ایسکمیک، شدت نورولوژیک،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی سیستم های درون ریز و اتونومیک
چکیده انگلیسی
It is not known whether combination of hypertension and high homocysteine (HHcy) impacts on stroke-related neurological severity. Our aim was to determine whether there is an interaction of hypertension and HHcy on neurological severity in first-ever ischemic stroke patients. We analyzed neurological severity among 189 consecutive first-ever ischemic stroke patients with or without hypertension or HHcy. Hypertension (odds ratio [OR]: 8.086, 95% confidence interval [CI]: 3.596-18.181, P < .001) and total homocysteine (OR: 1.403, 95% CI: 1.247-1.579, P < .001) were independently associated with neurological severity. In receiver-operating characteristic analysis, total homocysteine was a significant predictor of neurological severity (area under curve: 0.794; P < .001). A multiplicative interaction of hypertension and HHcy on more severe neurological severity was revealed by binary logistic regression (OR: 13.154, 95% CI: 5.293-32.691, P < .001). Analysis further identified a more than multiplicative interaction of hypertension and HHcy on neurological severity compared with patients without each condition (OR: 50.600, 95% CI: 14.775-173.285, P < .001). Interaction effect measured on an additive scale showed that 76.4% patients with moderate/severe neurological severity were attributed to interaction of hypertension and HHcy. Significant interaction of hypertension and HHcy on neurological severity was found on multiplicative and additive scale in first-ever Chinese ischemic stroke patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Society of Hypertension - Volume 12, Issue 7, July 2018, Pages 534-541
نویسندگان
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