کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8667485 | 1578002 | 2018 | 39 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Common variants at somatostatin are significantly associated with hypertension incidence in smoking and drinking populations
ترجمه فارسی عنوان
انواع رایج در سموتوستاتین به طور قابل توجهی با شیوع بالای فشار خون در افراد سیگاری و نوشیدن ارتباط دارد
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
سیستم های درون ریز و اتونومیک
چکیده انگلیسی
Somatostatin (SST) and growth hormone-releasing hormone (GHRH) are involved in the development of hypertension. This study aimed to evaluate whether SST and GHRH contribute to genetic susceptibility to hypertension. A case-control study consisting of 2012 hypertensive patients and 2210 matched control individuals was performed, and three tagging single-nucleotide polymorphisms were genotyped. The association of these single-nucleotide polymorphisms with hypertension and ischemic stroke was further evaluated among 4098 participants in a follow-up study. Hazard ratio (HR) and 95% confidence interval were estimated by Cox proportional hazards regression. The follow-up study indicated that in smoking population, variants at SST presented significant association with hypertension incidence; the adjusted HR of rs3755792 (GAÂ +Â AA vs. GG) was 0.634 (PÂ =Â .037), and the adjusted HR of rs7624906 (TCÂ +Â CC vs. TT) was 1.803 (PÂ =Â .005). In drinking population, rs3755792 at SST was associated with hypertension incidence, and the adjusted HR was 0.580 (PÂ =Â .009). Moreover, rs6032470 at GHRH had a statistical association with ischemic stroke incidence in smoking population, and the adjusted HR of the additive model was 1.625 (PÂ =Â .049). These results suggested that SST and GHRH harbor genetic susceptible loci with incident hypertension and ischemic stroke and that smoking and drinking might modify the genetic effect.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Society of Hypertension - Volume 12, Issue 3, March 2018, Pages 230-237.e12
Journal: Journal of the American Society of Hypertension - Volume 12, Issue 3, March 2018, Pages 230-237.e12
نویسندگان
Hui BS, Lijun MS, Zhengmei BS, Song MS, Yanchun MS, Yuelong MS, Xianghai MS, Chong PhD, Yingshui PhD,