کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8667507 | 1578004 | 2018 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Association of office and ambulatory blood pressure with blood lead in workers before occupational exposure
ترجمه فارسی عنوان
انجمن فشار خون اداری و آمبولانس با سرب خون در کارگران قبل از قرار گرفتن در معرض شغلی
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کلمات کلیدی
فشار خون، رهبری، طب کار، پرفشاری خون سفید کت،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
سیستم های درون ریز و اتونومیک
چکیده انگلیسی
In view of decreasing lead exposure and guidelines endorsing ambulatory above office blood pressure (BP) measurement, we reassessed association of BP with blood lead (BL) in 236 newly employed men (mean age, 28.6 years) without previous lead exposure not treated for hypertension. Office BP was the mean of five auscultatory readings at one visit. Twenty-four-hour BP was recorded at 15- and 30-minute intervals during wakefulness and sleep. BL was determined by inductively coupled plasma mass spectrometry. Systolic/diastolic office BP averaged 120.0/80.7 mm Hg, and the 24-hour, awake, and asleep BP 125.5/73.6, 129.3/77.9, and 117.6/65.0 mm Hg, respectively. The geometric mean of blood lead was 4.5 μg/dL (interquartile range, 2.60-9.15 μg/dL). In multivariable-adjusted analyses, effect sizes associated with BL doubling were 0.79/0.87 mm Hg (P = .11/.043) for office BP and 0.29/â0.25, 0.60/â0.10, and â0.40/â0.43 mm Hg for 24-hour, awake, and asleep BP (P â¥Â .33). Neither office nor 24-hour ambulatory hypertension was related to BL (P â¥Â .14). A clinically relevant white coat effect (WCE; office minus awake BP, â¥20/â¥10 mm Hg) was attributable to exceeding the systolic or diastolic threshold in 1 and 45 workers, respectively. With BL doubling, the systolic/diastolic WCE increased by 0.20/0.97 mm Hg (P = .57/.046). Accounting for the presence of a diastolic WCE, reduced the association size of office diastolic BP with BL to 0.39 mm Hg (95% confidence interval, â0.20 to 1.33; P = .15). In conclusion, a cross-sectional analysis of newly hired workers before lead exposure identified the WCE as confounder of the association between office BP and BL and did not reveal any association between ambulatory BP and BL.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Society of Hypertension - Volume 12, Issue 1, January 2018, Pages 14-24
Journal: Journal of the American Society of Hypertension - Volume 12, Issue 1, January 2018, Pages 14-24
نویسندگان
Wen-Yi MD, Ljupcho MD, Blerim MD, PhD, Zhen-Yu MD, Fang-Fei MD, Qi-Fang MD, PhD, Lutgarde MSc, Thomas MD, PhD, Tim S. PhD, Jan A. MD, PhD,