کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8667534 | 1578006 | 2017 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The relationship between hypertensive disorders in pregnancy and placental maternal and fetal vascular circulation
ترجمه فارسی عنوان
ارتباط بین اختلالات فشارخون در دوران بارداری و گردش خون عروقی مادر و جنین
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کلمات کلیدی
پرفشاری خون مزمن، پره اکلامپسی، جفت ضایعات مالپرفیوژن عروقی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
سیستم های درون ریز و اتونومیک
چکیده انگلیسی
We examined the impact of chronic hypertension (HTN), gestational HTN, and preeclampsia on placental maternal and fetal vascular circulation. Of the 1047 women who gave birth and underwent a placental histopathologic examination between 2007 and 2013 at Wolfson Medical Center, 140 women were included in the present study: 34 women with preeclampsia, 25 women with chronic HTN, 28 women with gestational HTN, and 53 women without hypertensive disorder, matched by age, gravidity, parity, and mode of delivery.Placental lesions related to maternal vascular malperfusion (MVM) differed significantly across groups (PÂ <Â .0001) and were highest in subjects with chronic HTN and preeclampsia (72% and 65%, respectively) and lowest in women without hypertensive disorder (26%). Placental fetal vascular malperfusion rate did not differ significantly between groups (PÂ =Â .767). In the logistic regression analysis, chronic HTN emerged as a significant predictor of placental MVM and increased the risk of this outcome more than sixfold (odds ratio 6.614, 95% confidence interval 2.047-21.37, PÂ =Â .002). Preeclampsia emerged as a significant predictor of MVM and more than tripled the risk of this outcome (odds ratio 3.468, 95% confidence interval 1.083-11.103, PÂ =Â .036). Gestational HTN was not significantly associated with increased MVM rate. We demonstrated that chronic HTN and preeclampsia were associated with an increased rate of vascular placental maternal malperfusion and emerged as significant independent predictors of this outcome.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Society of Hypertension - Volume 11, Issue 11, November 2017, Pages 724-729
Journal: Journal of the American Society of Hypertension - Volume 11, Issue 11, November 2017, Pages 724-729
نویسندگان
Michal MD, PhD, Jacob MD, MSc, Letizia MD, Marina MD,