کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8671850 1578809 2018 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chloroquine improves the response to ischemic muscle injury and increases HMGB1 after arterial ligation
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Chloroquine improves the response to ischemic muscle injury and increases HMGB1 after arterial ligation
چکیده انگلیسی
This paper evaluates the expression of high mobility group box 1 (HMGB1) in peripheral arterial disease (PAD). It further evaluates how HMGB1 expression can be increased by chloroquine, a commonly prescribed disease-modifying antirheumatic drug that improves blood flow in animal models of ischemia. We and others have shown that HMGB1 has strong proregenerative effects in muscle and may be a novel therapeutic target for patients with nonreconstructable PAD. Our study suggests that chloroquine administration may be a promising avenue for patients with severe PAD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Vascular Surgery - Volume 67, Issue 3, March 2018, Pages 910-921
نویسندگان
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