کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8674768 | 1578890 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cardiovascular risk markers among obese women using the levonorgestrel-releasing intrauterine system: A randomised controlled trial
ترجمه فارسی عنوان
علامت های خطرناک قلب و عروق در میان زنان چاق با استفاده از سیستم تولید داخل وریدی لوونورژسترل: یک کارآزمایی کنترل شده تصادفی
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کلمات کلیدی
چاقی، سندرم متابولیک، سیستم رحمی آزاد کننده لوونورژسترل، ضخامت اینتیام رسانه، آترواسکلروز،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی
According to international guidelines, women with obesity without other comorbidities can safely use any hormonal contraceptive (HC). However, limited information is available about contraceptive safety for women with obesity since obesity is an exclusion criterion of most contraceptive clinical trials. As such little is known about the possible risks of HC exposure for women with obesity without comorbidities. One way to assess possible long-term risks in this population, even prior to the development of any clinical disease, is to measure alterations in subclinical atherosclerosis markers. We evaluated the effects of the levonorgestrel-releasing intrauterine system (LNG-IUS) on subclinical markers of cardiovascular risk in women with obesity. This is a randomised clinical trial in which 106 women with obesity [body mass index (BMI) â¥Â 30 kg/m2] were randomised to the LNG-IUS (n = 53) or to non-hormonal methods (n = 53) and followed for 12 months. We evaluated waist circumference (WC), blood pressure, blood glucose, insulin, lipid profile, and endothelial function markers (carotid intima-media thickness, brachial artery flow-mediated dilation, and carotid arterial stiffness). At 12 months, BMI (p = 0.005), WC (p = 0.045), and glucose levels (p = 0.015) were significantly lower in the LNG-IUS group than in the control group. We did not find any clinically relevant changes in subclinical markers of cardiovascular risk among with obesity women at 12 months after LNG-IUS placement compared to users of non-hormonal contraceptive methods.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Obesity Research & Clinical Practice - Volume 11, Issue 6, NovemberâDecember 2017, Pages 687-693
Journal: Obesity Research & Clinical Practice - Volume 11, Issue 6, NovemberâDecember 2017, Pages 687-693
نویسندگان
Lucimara Facio Nobre Zueff, Anderson Sanches de Melo, Carolina S. Vieira, Wellington P. Martins, Rui A. Ferriani,