کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8679170 | 1579115 | 2017 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Comparison of del Nido and St Thomas Cardioplegia Solutions in Pediatric Patients: A Prospective Randomized Clinical Trial
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Comparison of del Nido and St Thomas Cardioplegia Solutions in Pediatric Patients: A Prospective Randomized Clinical Trial Comparison of del Nido and St Thomas Cardioplegia Solutions in Pediatric Patients: A Prospective Randomized Clinical Trial](/preview/png/8679170.png)
چکیده انگلیسی
We conducted a prospective randomized trial to compare del Nido (DN) cardioplegia with conventional cold blood cardioplegia (St Thomas [STH]) in pediatric patients. We randomized 100 pediatric patients aged â¤12 years undergoing elective repair of ventricular septal defects and tetralogy of Fallot to the DN and the STH groups. In the DN group, a 20âmL/kg single dose was administered. In the STH group, a 30âmL/kg dose was administered, followed by repeated doses at 25- to 30-minute intervals. The primary outcome was cardiac index that was measured 4 times intra- and postoperatively. Troponin-I, interleukin-6, and tissue necrosis factor-alpha were measured. Myocardial biopsy was obtained to assess electron-microscopic ultrastructural changes. Cardiac indices were significantly higher in the DN group than in the STH group 2 hours after termination of cardiopulmonary bypass (Pâ=â0.0006), after 6 hours (Pâ=â0.0006), and after 24 hours (Pââ¤â0.0001). On repeated measure regression analysis, the cardiac index was on an average 0.50 L/min/m2 higher in the DN group than in the STH group at any time point (Pâ=â0.002). Duration of mechanical ventilation (Pâ=â0.01), intensive care unit stay (Pâ=â0.01), and hospital stay (Pâ=â0.0007) was significantly lower in the DN group. Patients in the DN group exhibited lower troponin-I release 24 hours following cardiopulmonary bypass (Pâ=â0.021). Electron microscopic studies showed more myofibrillar disarray in the STH group (Pâ=â0.02). Use of long-acting DN cardioplegia solution was associated with better preservation of cardiac index, lesser troponin-I release, and decreased morbidity. Ultrastructural changes showed better preservation of myofibrillar architecture.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Thoracic and Cardiovascular Surgery - Volume 29, Issue 3, Autumn 2017, Pages 366-374
Journal: Seminars in Thoracic and Cardiovascular Surgery - Volume 29, Issue 3, Autumn 2017, Pages 366-374
نویسندگان
Sachin MCh, Amolkumar MCh, Vishnubhatla PhD, Neeti MD, Sudheer MD, Shiv Kumar MCh, Balram MCh,