کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8684272 1579883 2018 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Echocardiographic risk markers of sudden death in patients with temporal lobe epilepsy
ترجمه فارسی عنوان
نشانگرهای خطر اکوکاردیوگرافی مرگ ناگهانی در بیماران مبتلا به صرع لوب تمپورال
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی
Patients with epilepsy (PWE) have an increased risk for sudden unexpected death compared to the general population. Echocardiography can analyze structural and functional heart changes that have impact on outcomes, including sudden cardiac and all-cause death. Our hypothesis is that subtle heart abnormalities occur in PWE. Thirty patients with temporal lobe epilepsy without any known cardiovascular disease, followed for at least 1 year, were enrolled between July 2015 and July 2016 and submitted to a 12-lead electrocardiogram, treadmill test and transthoracic echocardiogram. PWE were matched with individuals without epilepsy by sex, age and body mass index. A literature review of studies comparing echocardiographic findings in PWE and individuals without epilepsy was performed. PWE had a higher left ventricle stiffness (β= 5.97 ± 0.05 × 5.94 ± 0.03; p = 0.02), left ventricle filling pressures (9.7 ± 1.3 mmHg × 9 ± 0.8; p = 0.02) and a greater left atrial volume (44.7 ± 13.6 ml × 34.1 ± 9.6 ml; p = 0.003). Seventeen (56.6%) PWE had a total of 22 of six known echocardiographic markers related to increased risk for sudden death in the general population, versus 11 (36.7%) controls with 12 markers (p = 0.07). Stiffness is related to fibrosis through extracellular matrix deposition, which promotes systolic and diastolic dysfunction and arrhythmogenesis. Subtle echocardiographic findings in PWE could help to explain why this population has an increased risk to die suddenly.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy Research - Volume 140, February 2018, Pages 192-197
نویسندگان
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