کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8684320 | 1579884 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Teratogenic and anticonvulsant effects of zinc and copper valproate complexes in zebrafish
ترجمه فارسی عنوان
اثرات تراتوژنیک و ضدتشنجی مجتمع های والپروات روی و مس در ماهی قزل آلا
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
چکیده انگلیسی
Valproic acid (VPA) is an antiepileptic drug (AED) that has the broadest spectrum across all types of seizures and epileptic syndromes. Unfortunately, approximately 30% of epileptic patients are refractory to the classical AED. Metal ions have been frequently incorporated into pharmaceuticals for therapeutic or diagnostic purposes and research. In this preliminary study, we assess the embryo toxicity and the anticonvulsant activity of 4 novel metallodrugs, with Zn+2 and Cu+2, a derivative of valproic acid and the N-donor ligand in an adult zebrafish epileptic seizure model induced by pentylenetetrazole. The most toxic complex was [Cu(Valp)2Bipy], in which the LC50 was 0.22â¯Î¼M at 48â¯h post fertilization (HPF) and 0.12â¯Î¼M at 96 HPF, followed by [Zn(Valp)2Bipy] (LC50â¯=â¯10â¯Î¼M). These same metallodrugs ([Cu(Valp)2Bipy] 10â¯mM/kg and [Zn(Valp)2Bipy] 30â¯mM and 100â¯mM/kg) displayed superior activity, thus reducing the seizure intensity by approximately 20 times compared to sodium valproate (175â¯mM/kg). Overall, [Cu(Valp)2Bipy] showed the best anticonvulsant effects. However, because of the toxicity of copper, [Zn(Valp)2Bipy] is considered the most promising anticonvulsant for future studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy Research - Volume 139, January 2018, Pages 171-179
Journal: Epilepsy Research - Volume 139, January 2018, Pages 171-179
نویسندگان
Lauren D. Grünspan, Ben Hur M. Mussulini, Suelen Baggio, Paulo R. dos Santos, Françoise Dumas, Eduardo P. Rico, Diogo L. de Oliveira, Sidnei Moura,