کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8685261 | 1580268 | 2018 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Paraneoplastic neuromyelitis optica spectrum disorder: A case report and review of the literature
ترجمه فارسی عنوان
اختلال طیف اپومینوپاتی نرویمیلیت پارانوپلاستی: گزارش مورد و بررسی ادبیات
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
چکیده انگلیسی
Neuromyelitis optica spectrum disorders (NMOSD) are demyelinating, autoimmune diseases affecting the central nervous system. Typically, recurrent optic neuritis and longitudinal extensive transverse myelitis dominates the clinical picture. In most cases NMOSD are associated with autoantibodies targeting the water channel aquaporin-4 (AQP-4). NMOSD usually present in young adults. Clinical findings suggestive of NMOSD in elderly patients should raise the suspicion of a paraneoplastic etiology. To our knowledge, we report the first case of a 66â¯year-old female patient with paraneoplastic NMOSD that is associated with squamous cell lung carcinoma. Anti-AQP-4 was present in both the serum and cerebrospinal fluid of the patient. However, immunhistological staining of the malignant tissue did not show presence of AQP-4 on the surface of tumour cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Neuroscience - Volume 48, February 2018, Pages 7-10
Journal: Journal of Clinical Neuroscience - Volume 48, February 2018, Pages 7-10
نویسندگان
Ádám Annus, Krisztina Bencsik, Izabella Obál, Zsigmond Tamás Kincses, László Tiszlavicz, Romana Höftberger, László Vécsei,