Serum sodium response to hypertonic saline infusion therapy in traumatic brain injury

- Few data are available characterizing sNa response to HTS infusion in TBI patients.
- sNa remained above 145 mEq/L beginning 32-36 h after initiation of HTS infusion.
- sNa decreased post-HTS infusion, beginning 12-24 hours following discontinuation.
- uNa correlated with HTS infusion rates during therapy and sNa decrease post-HTS.