کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8687584 1580948 2018 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
High field imaging of large-scale neurotransmitter networks: Proof of concept and initial application to epilepsy
ترجمه فارسی عنوان
تصویربرداری از میدان مغناطیسی در شبکه های انتقال دهنده عصبی در مقیاس بزرگ: اثبات مفهوم و کاربرد اولیه برای صرع
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی
The brain can be considered a network, existing of multiple interconnected areas with various functions. MRI provides opportunities to map the large-scale network organization of the brain. We tap into the neurobiochemical dimension of these networks, as neuronal functioning and signal trafficking across distributed brain regions relies on the release and presence of neurotransmitters. Using high-field MR spectroscopic imaging at 7.0 T, we obtained a non-invasive snapshot of the spatial distribution of the neurotransmitters GABA and glutamate, and investigated interregional associations of these neurotransmitters. We demonstrate that interregional correlations of glutamate and GABA concentrations can be conceptualized as networks. Furthermore, patients with epilepsy display an increased number of glutamate and GABA connections and increased average strength of the GABA network. The increased glutamate and GABA connectivity in epilepsy might indicate a disrupted neurotransmitter balance. In addition to epilepsy, the 'neurotransmitter networks' concept might also provide new insights for other neurological diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage: Clinical - Volume 19, 2018, Pages 47-55
نویسندگان
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