کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8687729 | 1580948 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hypometabolism of the posterior cingulate cortex is not restricted to Alzheimer's disease
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Hypometabolism of the posterior cingulate cortex is not restricted to Alzheimer's disease Hypometabolism of the posterior cingulate cortex is not restricted to Alzheimer's disease](/preview/png/8687729.png)
چکیده انگلیسی
When differential diagnosis of dementia includes both Alzheimer's disease (AD) and the behavioural variant of frontotemporal dementia (bvFTD), distribution of cerebral glucose metabolism as measured using [18F]â2âfluoroâ2âdeoxyâdâglucose positron emission tomography ([18F]FDG-PET) may be helpful. One important clue for differentiation is the presence of hypometabolism in the posterior cingulate cortex (PCC), usually associated with AD. PCC hypometabolism however, could also be present in bvFTD. Therefore, the specificity of PCC hypometabolism was examined. Based on visual reading PCC hypometabolism was present in 69-73/81 probable AD patients, in 10-16/33 probable bvFTD patients, and in 0-1/22 cognitive normal (CN) subjects. Findings were validated using a PCC to reference tissue [18F]FDG standard uptake value ratio (SUVr) cut-off, which was derived from the receiver operating characteristic (ROC) separating probable AD from CN, resulting in 9-14/33 bvFTD patients having PCC hypometabolism, depending on the reference tissue used. In conclusion, PCC hypometabolism is not restricted to AD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage: Clinical - Volume 19, 2018, Pages 625-632
Journal: NeuroImage: Clinical - Volume 19, 2018, Pages 625-632
نویسندگان
Nienke M.E. Scheltens, Kars van der Weijden, Sofie M. Adriaanse, Danielle van Assema, Priscilla P. Oomen, Welmoed A. Krudop, Adriaan A. Lammertsma, Frederik Barkhof, Teddy Koene, Charlotte E. Teunissen, Philip Scheltens, Wiesje M. van der Flier,