کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8688129 | 1580950 | 2018 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Grey matter volume and cortical structure in Prader-Willi syndrome compared to typically developing young adults
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کلمات کلیدی
ACCMPMTIVNHSOFCGLMPWSPFCMRI - امآرآی یا تصویرسازی تشدید مغناطیسیMagnetisation transfer - انتقال مغناطیسیupd - به روز رسانیintelligence quotient - بهره هوشیproton density - تراکم پروتونMagnetic resonance imaging - تصویربرداری رزونانس مغناطیسیtotal intracranial volume - حجم کل داخل جمجمهNational Health Service - خدمات بهداشت ملیflip angle - زاویه تلنگرecho time - زمان اکوRepetition time - زمان تکرارPrader-Willi syndrome - سندرم Prader-Willibody mass index - شاخص توده بدنBMI - شاخص توده بدنیcortical thickness - ضخامت قشرUniparental disomy - فساد اداریprefrontal cortex - قشر prefrontalorbitofrontal cortex - قشر اوربیتوفرنتالanterior cingulate cortex - قشر سینگولیت قدامی، کورتکس سینگولیت قدامیgrey matter - ماده خاکستریwhite matter - ماده سفیدGeneral linear model - مدل خطی کلیAnts - مورچه، مورMyelination - میلیناسیونGenomic imprinting - نشانه گذاری ژنومی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Prader-Willi syndrome (PWS) is a neurodevelopmental disorder of genomic imprinting, presenting with a characteristic overeating disorder, mild to moderate intellectual disability, and a variable range of social and behavioral difficulties. Consequently, widespread alterations in neural structure and developmental and maturational trajectory would be expected. To date, there have been few quantitative and systematic studies of brain morphology in PWS, although alterations of volume and of cortical organisation have been reported. This study aimed to investigate, in detail, the structure of grey matter and cortex in the brain in a sample of young adults with PWS in a well-matched case-controlled analysis. 20 young adults with PWS, aged 19-27Â years, underwent multiparameter mapping magnetic resonance imaging sequences, from which measures of grey matter volume, cortical thickness and magnetisation transfer saturation, as a proxy measure of myelination, were examined. These variables were investigated in comparison to a control group of 40 typically developing young adults, matched for age and sex. A voxel-based morphometry analysis identified large and widespread bilateral clusters of both increased and decreased grey matter volume in the brain in PWS. In particular, widespread areas of increased volume encompassed parts of the prefrontal cortex, especially medially, the majority of the cingulate cortices, from anterior to posterior aspects, insula cortices, and areas of the parietal and temporal cortices. Increased volume was also reported in the caudate, putamen and thalamus. The most ventromedial prefrontal areas, in contrast, showed reduced volume, as did the parts of the medial temporal lobe, bilateral temporal poles, and a small cluster in the right lateral prefrontal cortex. Analysis of cortical structure revealed that areas of increased volume in the PWS group were largely driven by greater cortical thickness. Conversely, analysis of myelin content using magnetisation transfer saturation indicated that myelination of the cortex was broadly similar in the PWS and control groups, with the exception of highly localised areas, including the insula. The bilateral nature of these abnormalities suggests a systemic biological cause, with possible developmental and maturational mechanisms discussed, and may offer insight into the contribution of imprinted genes to neural development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage: Clinical - Volume 17, 2018, Pages 899-909
Journal: NeuroImage: Clinical - Volume 17, 2018, Pages 899-909
نویسندگان
Katherine E. Manning, Roger Tait, John Suckling, Anthony J. Holland,