کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8688827 | 1580954 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Executive attention networks show altered relationship with default mode network in PD
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
ANTRIPsLIPsFPNTPNDMNRSNattention network test - آزمون شبکه توجهFunctional connectivity - اتصال عملکردی Resting state networks - استراحت شبکه های دولتیParkinson's disease - بیماری پارکینسونExecutive attention - توجه اجباریVentral attention network - شبکه توجه و تمرکزdefault mode network - شبکه حالت پیش فرضDorsal attention network - شبکه ی پشتیDAN - وVAN - وانTask positive network - کار شبکه مثبتhealthy controls - کنترل های سالم
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Attention dysfunction is a common but often undiagnosed cognitive impairment in Parkinson's disease that significantly reduces quality of life. We sought to increase understanding of the mechanisms underlying attention dysfunction using functional neuroimaging. Functional MRI was acquired at two repeated sessions in the resting state and during the Attention Network Test, for 25 non-demented subjects with Parkinson's disease and 21 healthy controls. Behavioral and MRI contrasts were calculated for alerting, orienting, and executive control components of attention. Brain regions showing group differences in attention processing were used as seeds in a functional connectivity analysis of a separate resting state run. Parkinson's disease subjects showed more activation during increased executive challenge in four regions of the dorsal attention and frontoparietal networks, namely right frontal eye field, left and right intraparietal sulcus, and precuneus. In three regions we saw reduced resting state connectivity to the default mode network. Further, whereas higher task activation in the right intraparietal sulcus correlated with reduced resting state connectivity between right intraparietal sulcus and the precuneus in healthy controls, this relationship was absent in Parkinson's disease subjects. Our results suggest that a weakened interaction between the default mode and task positive networks might alter the way in which the executive response is processed in PD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage: Clinical - Volume 13, 2017, Pages 1-8
Journal: NeuroImage: Clinical - Volume 13, 2017, Pages 1-8
نویسندگان
Peter Boord, Tara M Madhyastha, Mary K Askren, Thomas J Grabowski,