Immunohistochemical evaluation of VEGF and tryptase for angiogenesis and mast cell counting in giant cell granulomas of the jaws

The results may explain the different pathogenesis of these two lesions, despite the similarity in histopathologic features. Higher overall expression of VEGF in CGCGs might lead to increased vascularity as well as more destructive nature. More mast cells in PGCGs may explain the different pathogenesis of studied lesions.