کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8700580 | 1585620 | 2018 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mucinous adenocarcinoma with signet ring cell features of the sublingual gland: A case report with an immunohistochemical analysis
ترجمه فارسی عنوان
آدنوکارسینوم موکینوم با ویژگی های سلول های حلقوی مهره غدد زیر جلدی: گزارش مورد با یک روش ایمونوهیستوشیمی
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کلمات کلیدی
آدنوکارسینوما مزانشیمی، غدد لنفاوی، ویژگی سلول حلقه، ایمونوهیستوشیمی، پیش آگهی ضعیف
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
دندانپزشکی، جراحی دهان و پزشکی
چکیده انگلیسی
Mucinous adenocarcinoma (MAC) is a highly aggressive tumor, and its origin in the salivary glands is extremely rare. We report one case of salivary MAC showing highly invasive features with signet ring cells and immunohistochemical analysis. A 77-year-old Japanese woman who noticed painless swelling of the right floor of the mouth received surgical treatment and was diagnosed with primary MAC of the sublingual gland. The tumor consisted of two components: a glandular pattern and diffuse pattern with large mucinous lakes containing numerous signet ring cells. The tumor cells were immunopositive for CEA, CA125 and CK7 and strongly positive for Her-2 but negative for CK20, androgen receptor, GCDFP-15 and p63. The prognosis was poor, and the patient developed peritoneal metastasis and died. This case suggests that signet ring cell features in MAC may be a phenotype of aggression, and Her-2 may be a therapeutic target for MAC.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - Volume 30, Issue 3, May 2018, Pages 252-256
Journal: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - Volume 30, Issue 3, May 2018, Pages 252-256
نویسندگان
Masashi Nagata, Kimihide Kusafuka, Ryoji Yoshida, Kenta Kawahara, Yoshihiro Nakagawa, Masafumi Nakamoto, Masanori Shinohara, Hideki Nakayama,