Rapidly enlarging swelling of the palate: A case report

Undifferentiated high-grade pleomorphic sarcoma (UHPS)/pleomorphic sarcoma NOS (earlier MFH) is a soft tissue sarcoma which shows fibro-histiocytic morphology without a definitive lineage. These tumours are extremely rare in the head and neck region and account for only 0.1% of all sarcomas in the oral cavity. A rare case of UHPS of palate is hereby reported in a 55 year old female patient with emphasis on sequential diagnosis, pathogenesis, and evolution of current terminology. We also aim to address the role of immunohistochemical profiling in head and neck sarcomas and the impact of histo-differentiation on the prognosis of such patients.