In vivo confocal Raman spectroscopy for intrinsic aging and photoaging assessment

The wavenumber region between 798 and 994 cm−1 is useful for the analysis of dermal collagen alterations through the intrinsic aging process, while photoaging is better assessed by the I1275/I1450 intensities ratio. This is the first skin aging study to show a correlation between Raman peaks and the amount of collagen assessed by HFUS and histology.